Chest
Clinical InvestigationsIs Transplant Operation Important in Determining Posttransplant Risk of Bronchiolitis Obliterans Syndrome in Lung Transplant Recipients?
Section snippets
Transplant Population
Two hundred eighty-two lung transplant operations were performed at Duke University Medical Center between April 1992 and June 2000. Two hundred twenty-five patients survived for > 6 months after their transplant operation and are included in this report. The 6-month period from the time of transplantation was chosen in order to minimize the effect of events that occurred in the early posttransplant period and avoid the possibility that drops in lung function were due to other causes (like
Descriptive Characteristics
The median follow-up time for the patients was 2.4 years (interquartile range, 1.5 to 4.0 years). BOS was present in 93 of 225 patients (41.3%) at the time of the analysis. The pathologic diagnosis of OB was available in only 13.9% of patients (13 of 93 patients). All of these patients had met the spirometry criteria for BOS prior to the pathologic diagnosis. The median time to BOS development was 4.2 years (interquartile range, 3.0 to 4.8 years). The rates of freedom from BOS at 1, 2, 3, 4,
Discussion
This study presents data on the development of BOS in the lung transplant population from a single institution. It found a high incidence of BOS in lung transplant recipients, as has been described in previous studies.678910111213141516171819 Approximately 40% of the patients developed BOS by 4 years after transplantation. However, the median time to BOS development was 4.2 years, which is somewhat longer than that previously reported in the literature. Our transplant population received
References (32)
- et al.
Report of the xenotransplantation advisory committee of the International Society for Heart and Lung Transplantation: the present status of xenotransplantation and its potential role in the treatment of end-stage cardiac and pulmonary diseases
J Heart Lung Transplant
(2000) - et al.
Bronchiolitis obliterans after lung transplantation: a review
Chest
(1998) - et al.
Risk factors for the development of bronchiolitis obliterans syndrome after lung transplantation
Thorac Cardiovasc Surg
(1997) - et al.
Obliterative bronchiolitis after lung and heart-lung transplantation: an analysis of risk factors and management
Thorac Cardiovasc Surg
(1995) - et al.
Obliterative bronchiolitis after lung and heart-lung transplantation
Ann Thorac Surg
(1995) - et al.
Bronchiolitis obliterans in recipients of single, double and heart-lung transplantation
Chest
(1995) - et al.
Stanford experience with obliterative bronchiolitis after lung and heart-lung transplantation
Ann Thorac Surg
(1996) - et al.
Influence of panel-reactive antibodies on posttransplant outcomes in lung transplant recipients
Ann Thorac Surg
(2000) - et al.
Does hyperexpansion of the native lung adversely affect outcome after single lung transplantation for emphysema? Preliminary findings
Acad Radiol
(1998) - et al.
The Registry of the International Society for Heart and Lung Transplantation: eighteenth official report; 2001
J Heart Lung Transplant
(2001)