Chest
Original ResearchSleep DisordersCardiac Workload in Patients With Sleep-Disordered Breathing Early After Acute Myocardial Infarction
Section snippets
Patients
In this prospective, observational clinical study, consecutive patients with AMI who were referred to the University Hospital Regensburg, Regensburg, Germany, between March 2009 and June 2011 were evaluated for eligibility. Inclusion criteria were: age 18-80 years; first acute AMI with ST elevation on ECG or non-ST elevation with complete occlusion of coronary artery; and percutaneous coronary intervention (PCI) within 24 h after AMI. Patients were excluded if they had any of the following:
Patients
Of 220 consecutive patients with AMI, 55 were eligible for the study and were included in the analysis (Fig 1). Patient demographic characteristics, stratified by the presence or absence of SDB, are shown in Table 2. Patients with SDB were older (P = .013), more likely to be male (P = .020), more likely to have diabetes mellitus (P = .024), and had a higher BMI (P = .029) than those without SDB.
N-terminal pro-brain natriuretic peptide at admission and maximum creatine kinase levels were
Discussion
This study makes several novel observations. First, that patients in the early phase after AMI with CSA and OSA had higher 24-h systolic and diastolic BP, HR, and cardiac workload than similar patients without SDB. Second, although the association between SDB and systolic or diastolic BP was not significant after accounting for demographic variables, there was a significant relationship between SDB and both HR and cardiac workload after accounting for multiple potential confounders, including
Acknowledgments
Author contributions: Dr Arzt is the guarantor of the manuscript and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Dr Hetzenecker: contributed to the conception, hypotheses delineation, and design of the study; acquisition, analysis, and interpretation of the data; and writing and revising the article prior to submission.
Dr Buchner: contributed to the conception, hypotheses delineation, and design of the study; acquisition, analysis, and interpretation
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Funding/Support: This study was funded by Resmed; Philips Home Healthcare Solutions; and the Faculty of Medicine, University of Regensburg.
Drs Hetzenecker and Buchner contributed equally to this study.
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