Chest
Clinical InvestigationsASTHMADose-Response Relationship and Reproducibility of the Fall in Exhaled Nitric Oxide After Inhaled Beclomethasone Dipropionate Therapy in Asthma Patients
Section snippets
Subjects:
We recruited 15 asthmatic patients (8 male patients; age range, 17 to 40 years) with baseline Feno> 60 parts per billion (ppb; a value > 2 SD above mean values for healthy control subjects in our laboratory), in order to select subjects with increased baseline Feno. Asthma was diagnosed according to American Thoracic Society recommendations (1986). Exclusion criteria included the use of oral or inhaled corticosteroids, other anti-inflammatory agents, of long-acting β2agonists in the 4 weeks
Baseline Characteristics:
Fifteen subjects were recruited to the study. Geometric mean (95% confidence limit [CL]) baseline measurements were as follows: Feno, 103.5 ppb (78.5 to 136.7); PC20, 0.01 mg/mL (0.00 to 0.19); mean ± SD FEV1 and FVC at baseline were 3.01 ± 0.73 L (83.5 ± 16.6% predicted) and 4.49 ± 0.97 L (103.4 ± 12.2% predicted), respectively.
The Dose Response of the Fall in Feno:
The general model showed that the test for treatment differences in Feno was highly significant, indicating that at least two of the treatment means differed (p <
Discussion
Exhaled NO is widely regarded as a noninvasive marker of airway inflammation. In these two studies, we examined the dose response of sequential administration of increasing doses of iBDP on Feno, spirometry, and PC20, and also the reproducibility of the effect of a single dose of iBDP administered twice on Feno and spirometry. Exhaled NO, but not FEV1 or PC20, distinguished the 100-μg dose from the 800-μg/d dose of iBDP. The effect of repeated administration of 200 μg/d of iBDP on both Fenoand
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This study was sponsored by Novex Pharma Ltd, Richmond Hill, Ontario, Canada.