Chest
Clinical InvestigationsTransbronchial Lung Biopsy: Histopathologic and Morphometric Assessment of Diagnostic Utility
Section snippets
Materials and Methods
One hundred twenty-two adult patients undergoing TBB were identified from the files of two Baylor College of Medicine Affiliated Hospitals (Ben Taub General Hospital and The Methodist Hospital), in Houston, Tex. The clinical records at the time of hospital admission and during subsequent follow-up (12 months or more) were searched for clinical and roentgenographic diagnoses. Tissues from the TBB specimens were fixed in buffered formaldehyde and embedded in paraffin. The tissue slides were
Results
Diagnoses of infection, tumor, and nonspecific diagnosis were made in 28 (24 percent), 25 (21.6 percent), and 63 (54.3 percent) of the 116 TBB specimens, respectively. However, on clinical follow-up (12 months or longer), 41 (65 percent) of the 63 patients with nonspecific diagnosis were subsequently found to have a specific diagnosis of either infection or tumor. Most infection diagnoses were made in younger men with the acquired immunodeficiency syndrome. Of the 28 infections, 16 cases were
Discussion
Transbronchial biopsy is well-recognized as a useful diagnostic tool in the study of lung disease.7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17 However, there are factors that may limit the utility of TBB. These factors are generally believed to be related to its small size or unrepresentativeness of the tissue specimen or both. It is also recognized that nonalveolated (bronchial wall) tissue samples are much less likely to yield a diagnosis than alveolated tissue samples.22 However, our review of
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Inadequate (Ax) Transbronchial Lung Transplant Biopsies—Scope and the Potential Contributing Factors
2024, Transplantation ProceedingsUtility of Transbronchial vs Surgical Lung Biopsy in the Diagnosis of Suspected Fibrotic Interstitial Lung Disease
2017, ChestCitation Excerpt :Standard TBB has been used widely for obtaining lung samples for histologic evaluation. The diagnostic yield is variable and is influenced by factors such as the size of the samples harvested and the presence of crush artifacts left by conventional biopsy forceps.40-42 Methods of approaching TBB to best achieve an adequate diagnostic specimen have not been determined, particularly with respect to the diagnosis of UIP with its peripheral lung predominance.43
Endobronchial ultrasonography with a guide sheath in the diagnosis of benign peripheral diseases
2012, Annals of Thoracic SurgeryCitation Excerpt :Our main goal in this report was to define retrospectively the efficacy of benign pulmonary diseases, especially nodular lesions, when using bronchoscopy with EBUS-GS. Fraire and associates [16] reported that the diagnostic usefulness of TBB is related to the specimen size, especially in benign diseases. In the present study, we postulated that the size of biopsy specimens would influence the diagnostic yields of benign diseases, but the diagnostic yields did not vary with the diameter of biopsy forceps (59% versus 58%).
Usefulness of transbronchial and surgical biopsies for the management of interstitial lung disease
2005, Revue de Pneumologie CliniqueA contributive result of open-lung biopsy improves survival in acute respiratory distress syndrome patients
2007, Critical Care MedicineMicromorphological features and interleukin 6, 8, and 18 expressions in post-mortem lung tissue in cases with acute respiratory distress syndrome
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Manuscript received August 30; revision accepted December 2