Chest
Original ResearchSleep DisordersCirculating Microparticles in Children With Sleep Disordered Breathing
Section snippets
Study Subjects
Consecutive, healthy, habitually snoring and nonsnoring prepubertal children (aged 4-12 years) participating in a study on neurocognitive function and sleep in children at the University of Louisville Pediatric Sleep Medicine Center were recruited to investigate endothelial function in the context of OSA. All methods outlined in this study were approved by the University of Louisville Human Research Committee (protocol 474.99), and informed consent was obtained from the legal caregiver of each
Study Population
Based on the presence or absence of habitual snoring and the AHI score, 65 children had mild OSA, 14 children had moderate to severe OSA, and 56 were control subjects. The demographic, polysomnographic, and biochemical characteristics of the three groups are shown in Table 1. Mean age, gender and ethnic BPs and mean arterial pressures were significantly elevated in the children with OSA. The BMI z scores and the log MRP 8/14 and apolipoprotein B levels also showed significant group differences (
Discussion
This study shows that pediatric OSA leads to severity-related increases in the number of cell-derived MPs in the peripheral blood and to increased risk for altered endothelial function,18, 39 particularly in the presence of more severe disease. Furthermore, platelet-derived MPs along with BMI z scores accounted for a significant portion of the variance in postocclusive hyperemic responses in the stepwise multivariate regression model (Table 3), with BMI z scores, an AHI > 1 event per hour of
Acknowledgments
Authors contributions: Dr Gozal had full access to the data and will vouch for the integrity of the data analysis.
Dr Kim: contributed to conducting flow cytometry assays, conducting preliminary data analyses, and initial drafting of the manuscript.
Dr Bhattacharjee: contributed to recruiting subjects, performing vascular function studies, and reviewing the manuscript.
Dr Kheirandish-Gozal: contributed to recruiting subjects, performing vascular function studies, and drafting and revising the
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2023, Snoring and Obstructive Sleep Apnea in ChildrenCirculating exosomes in obstructive sleep apnea as phenotypic biomarkers and mechanistic messengers of end-organ morbidity
2018, Respiratory Physiology and NeurobiologyCitation Excerpt :In addition, circulating EVs/exosomes have been associated with various diseases severity. For examples, these vesicles have been suggested for clinical biomarkers for OSA (Ayers et al., 2009; Kim et al., 2011; Yun et al., 2010), for pulmonary hypertension (Amabile et al., 2008; Bakouboula et al., 2008), for sepsis (Mostefai et al., 2008), and for COPD (Takahashi et al., 2012; Thomashow et al., 2013). A potential challenge in the development of non-invasive diagnostic assays based on exosome analysis in body fluids is the ability to identify the clinically relevant cluster of exosomes from all the other numerous exosomes.
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2017, Revue de Pneumologie CliniqueDiagnosis of pediatric obstructive sleep apnea: Preliminary findings using automatic analysis of airflow and oximetry recordings obtained at patients' home
2015, Biomedical Signal Processing and ControlCitation Excerpt :OSAS can affect both adults and children. Common symptoms in children include overnight snoring and sleep difficulties [2], which may derive in other daytime symptoms and illnesses such as cognitive and behavioral irregularities, abnormal growth, and cardiovascular risks [3,4]. Moreover, pediatric OSAS is known to be underdiagnosed [5], and the scientific literature reports up to 6% of children affected [3].
Biomarkers associated with obstructive sleep apnea and morbidities: A scoping review
2015, Sleep MedicineCitation Excerpt :Obstructive sleep apnea (OSA) has now been recognized as a major public health issue with potential society-wide consequences involving car or work-related accidents, cognitive and behavioral deficits impairing work performance, and potentially leading to cardiovascular and metabolic dysfunction [1]. Indeed, OSA has been associated with serious morbidities such as endothelial dysfunction [2,3], hypertension [4], cardiovascular disease (CVD) [5–7], cognitive and behavioral dysfunction [8], metabolic disorders such as insulin resistance [9], diabetes [10], and dyslipidemias [11], erectile dysfunction in men [12], nocturnal enuresis in children [13], and excessive daytime sleepiness (EDS) [14,15]. Consequently, healthcare costs are substantially increased in patients with OSA, accounting either directly or via its associated morbidities for a substantial proportion of all medical-related costs [16–18].
Funding/Support: Dr Gozal's work is funded by the National Institutes of Health [Grant HL65270].
Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (http://www.chestpubs.org/site/misc/reprints.xhtml).