Asthama, Rhinitis, Other Respiratory DiseasesEarly life risk factors for adult asthma: A birth cohort study of subjects at risk☆,☆☆,★
Section snippets
Methods
One hundred subjects were enrolled before birth over a 12-month period from 1976 to 1977. All babies were born in Poole Hospital and were selected on the basis of one or both parents having a history of asthma, hay fever, or both. Informed consent was obtained, and the local ethical committee approved all stages of the study.
The cohort was studied every 3 months for the first year, annually thereafter until the age of 5 years, and again at 11 years. This study reports on the latest follow-up of
Results
One hundred children were recruited at birth. Nineteen children dropped out within the first 2 years, and information on these subjects is limited. Seventy-three subjects remained in the study at 5 years, and 67 remained at 11 years. At 22 years, 60 subjects were recalled for study, and a further 3 subjects returned questionnaires only. The early life characteristics of the 63 subjects who were studied at 22 years were compared with those of the 18 subjects who were lost to follow-up after
Discussion
In this birth cohort study of 63 subjects with atopic parents, 25% of the subjects had asthma in adult life. Wheezing before the age of 2 years did not predict adult asthma, but wheezing between the 10th and 11th birthday was highly predictive. A positive skin prick test response to hen's egg, cow's milk, or both in the first year of life was independently predictive of adult asthma. Total serum IgE levels were significantly related to adult asthma by the age of 11 years. We studied a number of
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Supported as part of the NHS National Research and Development Programme on Asthma Management.
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The views and opinions expressed herein do not necessarily reflect those of the Department of Health.
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Reprint requests: Helen Rhodes, MB, ChB, Room EG228, Mail Point 43, Southampton General Hospital, Tremona Rd, Southampton, UK, SO16 6YD.