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Dendritic cells capable of stimulating T cells in germinal centres

Nature volume 384, pages 364–367 (1996)Cite this article

Abstract

THE B cells within the germinal centres of lymphoid organs undergo affinity maturation of their antigen receptors, a critical event for antibody memory1–3. Follicular dendritic cells within the germinal centres retain immune complexes4–6 that select the developing B cells for which they have a higher affinity7. We have now identified a subset of CD4+CD11c+CD3− dendritic cells in the germinal centres. These are strong antigen-presenting cells for T cells, but do not co-stimulate CD40-activated B cells. These dendritic cells probably stimulate germinal centre T cells and aid the complicated processes that are required for the generation of memory B cells.

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Authors and Affiliations

  1. Schering-Plough, Laboratory for Immunological Research, 27 chemin des Peupliers, BP 11, 69571, Dardilly, France

    Géraldine Grouard, Isabella Durand, Jacques Banchereau & Yong-Jun Liu

  2. Institute of Anatomy, Division of Cell Biology, University Irchel–Zurich, 8057, Zurich, Switzerland

    Luis Filgueira

Authors
  1. Géraldine Grouard
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  2. Isabella Durand
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  3. Luis Filgueira
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  4. Jacques Banchereau
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  5. Yong-Jun Liu
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Grouard, G., Durand, I., Filgueira, L. et al. Dendritic cells capable of stimulating T cells in germinal centres. Nature 384, 364–367 (1996). https://doi.org/10.1038/384364a0

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