Report on a WHO Consultation on the characterisation of BCG strains, Imperial College, London 15–16 December 2003
Section snippets
Recommendations
- 1.
The current recommendations for BCG vaccines need to be reviewed in the light of current knowledge and the best available methods. The review should also consider the definition and nomenclature of BCG sub-strains in the light of new information. It should also take account of the position of the current standard, the replacement/development of appropriate standards and their application.
- 2.
Currently, it was not feasible to conduct clinical trials to compare the efficacy and safety of currently
References (15)
- et al.
A historical and molecular phylogeny of BCG strains
Vaccine
(1999) - et al.
The in vitro evolution of BCG vaccines
Vaccine
(2003) - et al.
Development of a tetrazolium salt assay for rapid determination of viability of BCG vaccines
Vaccine
(1999) - et al.
Identification of sub-strains of BCG vaccine using multiplex PCR
Vaccine
(2001) - WHO Expert Committee on Biological Standardization. Requirements for freeze-dried BCG vaccine. WHO Technical Rep Ser...
- WHO Expert Committee on Biological Standardization. Requirements for BCG vaccines-addendum. WHO Technical Rep Ser No...
- et al.
Genomic interrogation of the Dassie bacillus reveals it as a unique RD1 mutant within theMycobacterium tuberculosis complex
J. Bacteriol.
(2004)
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Multiplex-PCR as an identity assay for Mycobacterium bovis BCG Moreau descendants
2013, BiologicalsCitation Excerpt :The original Bacille Calmette–Guérin attenuated strain distributed worldwide for production of vaccine against TB evolved differently around the world due to specific manufacturing conditions [1], resulting in the generation of more than 49 recognized BCG substrains [2].
Report of an international collaborative study to evaluate the suitability of multiplex PCR as an identity assay for different sub-strains of BCG vaccine
2010, VaccineCitation Excerpt :In 2003, WHO initiated a project to revise the current requirements for dried BCG vaccine. Collective international opinion derived from three WHO consultation meetings on BCG vaccine has highlighted the importance of genetic characterisation of different BCG sub-strains used in vaccine production [16–18]. A more specific identification method for BCG vaccine is required to replace non-specific acid fast staining.
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