Elsevier

Respiratory Medicine

Volume 106, Issue 11, November 2012, Pages 1526-1534
Respiratory Medicine

Effect of anti-inflammatory supplementation with whey peptide and exercise therapy in patients with COPD

https://doi.org/10.1016/j.rmed.2012.07.001Get rights and content
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Summary

Background

One of the major pathophysiologies in advanced chronic obstructive pulmonary disease (COPD) has been attributed to systemic inflammation. Meta-analysis of the 2005 Cochrane Database concluded the effect of nutritional supplementation alone on stable COPD was insufficient to promote body weight gain or exercise capacity. The aim of this study was to investigate the effectiveness of nutritional supplementation therapy using a nutritional supplement containing whey peptide with low-intensity exercise therapy in stable elderly patients with COPD.

Method

In stable elderly COPD patients with %IBW and %FEV1 of less than 110 and 80%, respectively, anti-inflammatory nutritional supplementation therapy was added to low-intensity exercise therapy. Thirty-six COPD patients were divided into those with and those without the ingestion of an anti-inflammatory nutritional supplement containing whey peptide, which exhibited an anti-inflammatory effect. These two groups were designated as the nutritional support and the control groups, respectively. The body composition, skeletal muscle strength, exercise tolerance, health-related QOL (HRQOL), and inflammatory cytokines were evaluated before and three months after nutritional support combined with exercise therapy in both the nutritional support group and the control group.

Results

In the nutritional support group, the body weight, %IBW, FM, energy intake, %AC, Alb, PImax, PEmax, 6MWD, WBI, emotional function, and CRQ total were significantly increased, and the levels of hsCRP, IL-6, IL-8, and TNF-α were reduced significantly, while no significant change was noted in any item of physiological evaluation or any biomarker in the control group.

Conclusion

Concomitant use of a anti-inflammatory nutritional supplement containing whey peptide, which exhibits an anti-inflammatory effect, with exercise therapy in stable elderly COPD patients with %IBW < 110% and %FEV1 < 80% may not only increase body weight but may also inhibit systemic inflammation and thus improve exercise tolerance and HRQOL.

Keywords

Chronic obstructive pulmonary disease (COPD)
Anti-inflammatory nutritional supplementation therapy
Whey peptide
Pulmonary rehabilitation

Abbreviations

%IBW
%ideal body weight
FM
fat mass
%AC
%arm circumference
PImax
maximum inspiratory mouth pressure
PEmax
maximum expiratory mouth pressure
6MWD
6-minute walking distance
WBI
weight bearing index
CRQ
chronic respiratory disease questionnaire

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