Asthma and lower airway diseasePrenatal determinants of neonatal lung function in high-risk newborns
Section snippets
Study design
The study was conducted in accordance with the guiding principles of the Declaration of Helsinki and approved by the Ethics Committee for Copenhagen (KF 01-289/96) and the Danish Data Protection Agency (2008-41-1754). Before enrollment, informed consent was obtained from both parents. Data validity and quality control procedures followed “Good Clinical Practice” guidelines. History was recorded online during visits to the COPSAC clinical research unit. Objective assessments were double-checked
Results
Lung function was analyzed in 404 of 411 infants. The median age was 6 weeks at the time of testing. Mean birth length was 52.3 cm and birth weight 3.52 kg. BMI at birth for girls was 12.84 ± 1.25 and for boys was 12.77 ± 1.37. The covariants analyzed together with univariate analyses of their estimated effect on the baseline FEV0.5 and PD15(PTcO2) are presented in Table E1.
Summary of principal findings
Baseline FEV0.5 was 14% lower in neonates with BMI in the upper quartile and 7% lower in neonates whose mothers reported smoking during pregnancy.
Maternal intake of paracetamol during the third trimester was associated with increased bronchial responsiveness (PD15[PtcO2] reduced) in the neonates, but the statistical significance may have been driven by outliers, as suggested from the lack of significance in the robustness test, taking such outliers into account.
Bronchial responsiveness
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The Copenhagen Prospective Studies on Asthma in Childhood are supported by private and public research funds. Grants above 100.000 Euro were donated by the Lundbeck Foundation, the Pharmacy Foundation of 1991, the Augustinus Foundation, the Danish Medical Research Council, and the Danish Pediatric Asthma Center.
Disclosure of potential conflict of interest: H. Bisgaard has been a consultant to, has been a paid lecturer for, and holds sponsored grants from Aerocrine, AstraZeneca, Altana, GlaxoSmithKline, Merck, MedImmune, NeoLab, and Pfizer. His employer, the Danish Pediatric Asthma Center, has received unrestricted institutional grants from Aerocrine, AstraZeneca, GlaxoSmithKline, Merck, and MedImmune and has provided legal consultation for NeoLab. The rest of the authors have declared that they have no conflict of interest.