Asthma diagnosis and treatmentAsthma medication use in pregnancy and fetal growth
Section snippets
Study population
Subjects were participants in a prospective multicenter controlled cohort study of asthma medication use in pregnancy conducted between 1998 and 2003 by the Organization of Teratology Information Services (OTIS). The methodology of the OTIS Asthma Medications in Pregnancy Project has been described elsewhere.22 Briefly, pregnant women across North America with a current diagnosis of asthma, regardless of medications used or frequency of treatment, were eligible to enroll. Pregnant women who did
Results
In the β2-agonist group, 96.1% of women used albuterol, 10.7% salmeterol, 4.9% terbutaline, 1.0% pirbuterol, 1.0% formoterol, and 1.0% fenoterol. In the ICS group, 53.2% of women used fluticasone, 29.9% beclomethasone, 21.9% budesonide, 13.0% triamcinolone acetonide, and 3.0% flunisolide. The majority of women in the systemic corticosteroid group used prednisone (92.9%), 6.2% methylprednisolone, and 0.9% dexamethasone. Most women in the ICS and systemic corticosteroid groups (94.7%) also used β2
Discussion
Results of this study demonstrate that use of β2-agonists or ICSs for treatment of asthma during pregnancy does not impair any parameters of fetal growth compared with controls without asthma. A small decrease of approximately 200 g in birth weight was observed among infants born to women who used systemic corticosteroids any time during pregnancy relative to exclusive β2-agonist users and to controls without asthma. Mean birth length of full-term infants in the systemic corticosteroid group
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Disclosure of potential conflict of interest: L. Bakhireva, none disclosed; K. L. Jones, none disclosed; M. Schatz received grants/research support from GlaxoSmithKline and serves on the speakers' bureau for AstraZeneca and Merck; D. Johnson, none disclosed; C. Chambers, none disclosed.