Environmental and occupational respiratory disordersEvaluation of the CD14/-260 polymorphism and house dust endotoxin exposure in the Barbados Asthma Genetics Study
Section snippets
Study population
The population of Barbados is primarily of African descent with approximately 25% European admixture, similar to that observed in African Americans.18 Families were recruited in Barbados as a part of an ongoing asthma genetics study initiated in 1993.19, 20 Briefly, asthmatic probands were recruited from all regions of the island, including 6 polyclinics, 2 private clinics, and the Accident and Emergency Department of Queen Elizabeth Hospital. Patients with a positive family history of asthma
Subject characteristics and genotype data
Baseline characteristics of the study population by asthma status (and ignoring family structure) are summarized in Table I. There was no sex difference between subjects with and without asthma; however, subjects without asthma were, on average, twice as old as subjects with asthma. Given that this sample consists of families recruited through children with asthma and their parents, such an age difference is expected. Also as expected, subjects with asthma had a significantly higher asthma
Discussion
Individuals of African descent are at increased risk for asthma and atopic disease compared with European and European-American populations, and they have a more severe disease, even after controlling for factors such as access to medical care and socioeconomic status. Differences in genetic risk factors may contribute to these health disparities. We genotyped 747 individuals from 125 pedigrees (327 nuclear families) for the CD14-260 polymorphism and found the frequency of the -260T allele was
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Supported by National Institutes of Health grant A120059, Allergy and Asthma Foundation of America Young Investigator Award (K.C.B.). K.C.B. was supported in part by the Mary Beryl Patch Turnbull Scholar Program. Dr Zambelli-Weiner was supported by a training grant in Environmental Health Sciences (T32 ESO7141) from the Johns Hopkins Bloomberg School of Public Health.