Pre-Clinical ResearchMajor Role for Hypoxia Inducible Factor-1 and the Endothelin System in Promoting Myocardial Infarction and Hypertension in an Animal Model of Obstructive Sleep Apnea
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Key Words
obstructive sleep apnea
myocardial infarction
hypoxia inducible factor-1
gene expression
endothelin
Abbreviations and Acronyms
CPAP
continuous positive airway pressure
ET
endothelin
HIF
hypoxia-inducible factor
HRE
hypoxia response element
IH
intermittent hypoxia
MABP
mean arterial blood pressure
N
normoxia
OSA
obstructive sleep apnea syndrome
PCR
polymerase chain reaction
SHR
spontaneous hypertensive rats
WKY
Wistar Kyoto rats
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This study was supported, in part, by a grant from AGIRà dom (Grenoble, France). Dr. Launois is the recipient of an AREA award from Actelion Pharmaceuticals for a clinical project on sleep apnea patients.
Copyright © 2009 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.