Immunity
Volume 33, Issue 5, 24 November 2010, Pages 699-712
ArticleSTAT6 Transcription Factor Is a Facilitator of the Nuclear Receptor PPARγ-Regulated Gene Expression in Macrophages and Dendritic Cells
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open access
Graphical Abstract
Highlights
► Proinflammatory cytokines inhibit and IL-4 stimulates PPARγ activity in macrophages ► IL-4 acts as an upstream regulator of PPARγ signaling via STAT6 ► STAT6 and PPARγ bind to target gene promoters together and physically interact ► STAT6 promotes PPARγ binding and facilitates its transcriptional activity
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Present address: Department of Molecular Biology, Massachusetts General Hospital, Department of Genetics, Harvard Medical School, Howard Hughes Medical Institute, Richard Simches Research Building, 185 Cambridge St., Boston, MA 02114, USA
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