Original articleGeneral thoracicImpact of Pulmonary Function Measurements on Long-Term Survival After Lobectomy for Stage I Non-Small Cell Lung Cancer
Section snippets
Patients and Methods
After obtaining Institutional Review Board approval, all patients who underwent lobectomy for NSCLC at Duke University Medical Center between the years 1996 and 2012 were reviewed. Only patients who underwent standard or sleeve lobectomy without previous chemotherapy or radiation for stage I (T1-2N0M0) NSCLC were included; patients who had bilobectomy were excluded. Stage was recorded based on the American Joint Committee on Cancer, seventh edition, staging system; patients treated during times
Results
Lobectomy was performed for stage I NSCLC in 972 patients who met all study criteria during the study period. Demographics, baseline characteristics, and comorbid conditions are shown in Table 1. The mean percent predicted Dlco for the cohort was 76% ± 21%, and the mean percent predicted FEV1 was 73% ± 21%. A minority of patients had either percent predicted Dlco or percent predicted FEV1 greater than 80% before surgery (28% of patients for each). There were 305 patients (31%) who had either
Comment
The results of this study quantify the impact of lower PFTs on survival after lobectomy for stage I NSCLC. Long-term overall survival when patients had either percent predicted Dlco or FEV1 greater than 80% was significantly better than when those values were less than 80%. However, decreasing values of FEV1 and Dlco had different associations with survival. The survival of patients with percent predicted FEV1 less than 80% was worse than that of patients with higher FEV1, although the
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