Clinical research studyCOPD as a Systemic Disease: Impact on Physical Functional Limitations
Section snippets
Overview
The Function, Living, Outcomes, and Work (FLOW) study of COPD is an ongoing prospective cohort study of adult members of an integrated health care delivery system with a physician's diagnosis of COPD and a matched referent group without COPD. At baseline assessment, we conducted structured telephone interviews that ascertained COPD status, health status, self-reported functional limitations, sociodemographic characteristics, and physician-diagnosed comorbidities. Subjects then underwent a
Characteristics of Subjects With and Without COPD
By design, subjects with and without COPD were similar in age, sex, and race-ethnicity (P>.20 in all cases) (Table 1). The prevalence of lifetime smoking was much higher among those with COPD (87%) than in the referent group (48%) (P<.0001). Persons with COPD also had lower social class, as evidenced by lower educational attainment and household income. As expected, pulmonary function was markedly poorer in the COPD group (Table 2). The prevalence of cardiovascular disease (22 vs 3%) and
Discussion
COPD was related to a broad array of physical functional limitations compared to a matched referent group without the disease, including lower extremity functioning, exercise performance, skeletal muscle strength, and self-reported limitation in basic physical actions. These physical functional limitations are directly attributable to COPD, because patients with and without COPD were recruited from the same source population of managed care patients and were matched by age, sex, and race. For
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Funded by: NHLBI/NIH R01HL077618.