Original investigationReproducibility and Validity of Lung Density Measures from Cardiac CT Scans—The Multi-Ethnic Study of Atherosclerosis (MESA) Lung Study1
Section snippets
Study Sample
The Multi-Ethnic Study of Atherosclerosis (MESA) is a multicenter prospective cohort study to investigate the prevalence, correlates, and progression of subclinical cardiovascular disease in individuals without clinical cardiovascular disease. The protocol and recruitment has been previously described (18). MESA recruited 6814 participants, ages 45–84 years old, of non-Hispanic white, African-American, Hispanic, or Chinese race/ethnicity from six United States communities in 2000–2002. Major
Results
Table 2 shows the characteristics of participants in the reproducibility study of cardiac CT scans, the comparability study of EBCT versus MDCT cardiac CT scans, and the validation study of cardiac versus full-lung CT scans. One participant selected for the reproducibility study underwent one instead of two baseline scans and was excluded from baseline analyses; two participants were excluded from follow-up analyses for the same reason. Participants ranged in age from 45 to 84 years. A majority
Discussion
Percent emphysema and alpha ascertained from cardiac CT scans were reproducible and yielded similar results, on average, to lung density measures from full-lung scans among relatively healthy participants. Reproducibility did not differ consistently by scanner type and values of percent emphysema and alpha from cardiac scans acquired on an EBCT scanner were comparable to those acquired on an MDCT scanner.
The reproducibility of lung density measures from paired cardiac scans in this multicenter
Acknowledgment
The authors thank the other investigators, the staff, and the participants of the MESA and MESA-Lung studies for their valuable contributions, and particularly acknowledge the assistance of Matthew Budoff, MD, PhD, W. Craig Johnson, MS, and Angel Solano for assistance with the completion of the study. A full list of participating MESA investigators and institutions can be found at http://www.mesa-nhlbi.org.
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Conflict of interest: Drs. Hoffman and Reinhardt are founders and shareholders of VIDA Diagnostics Inc., a company that is commercializing portions of the image analysis software used in this study.
Supported by contracts R01 HL-077612, R01 HL-075476, N01-HC-95159 through N01-HC-95165 and N01-HC-95169 from the National Heart, Lung, and Blood Institute, Bethesda, MD.