Original ArticlesMaximal exercise capacity and peripheral skeletal muscle function following lung transplantation☆
Section snippets
Methods
Data for 19 subjects (10 males, 9 females), 37.5 (19.5–60.9) months (median [interquartile range]) post-transplantation was collected as part of their standard clinical care. These patients were grouped as either single- (SLT) or double lung transplantation (DLT). Fifteen of these subjects were more than 18 months post-transplantation. In each group, 2 subjects were less than 18 months (6–7 months and 12 months) post-transplantation. The SLT group consisted of 10 subjects with the following
Results
The DLT group was significantly younger than the SLT group (Table I). Both groups were mildly anemic as evidenced by their low hemoglobin values (11.0 [10.3–11.9] gm/dl and 10.6 [10.0–11.4] gm/dl for the SLT and DLT groups respectively, p > .5). The Body Mass Index (BMI) and lean body mass was similar for the two groups.
The whole blood trough cyclosporine A levels and daily prednisone dose for the SLT and DLT groups were found to be similar (279.5 mg [234.0–307.0] vs 265.0 mg [169.0–291.0] and
Discussion
Our patients, like those reported by other groups,1, 2, 3 demonstrated a marked reduction in exercise capacity, regardless of the type of surgical intervention. The major factor associated with this reduced exercise ability was a diminished peripheral skeletal muscle work capacity. Cardiac output was appropriate for the amount of work performed. In contrast to leg muscle weakness, respiratory muscle strength was preserved.
Despite having acceptable BMI’s, our patients demonstrated reduced leg
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This study was funded in part by the Association Pulmonaire du Québec.
- 1
Dr. Lands is a chercheur-clinicien of the Fonds de Recherche en Santé du Québec.