An ancient system of host defense

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Abstract

Research over the past few years has begun to provide significant advances in our understanding of the interplay between the innate and adaptive immune systems. New findings in several model systems reveal remarkable parallels and conservation of ancient host defense pathways in organisms separated by over a billion years of evolution.

Abbreviations

IL Interleukin
IRAK IL-1 receptor-associated kinase
LRR Leucine-rich repeats
SIIK Serine/threonine innate immunity kinase

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