CommentRevising the immunological theories of asthma and allergy
References (11)
The role of lymphocytes in allergic disease
J Allergy Clin Immunol
(2000)- et al.
Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties
Annu Rev Immunol
(1989) - et al.
Two types of mouse helper T-cell clone: implications for immune regulation
Immunol Today
(1987) - et al.
Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation
J Clin Invest
(1999) - et al.
Modulation of airway inflammation by passive transfer of allergen-specific Th1 and Th2 cells in a mouse model of asthma
J Immunol
(1999)
Cited by (24)
Sialic acid–modified der p 2 allergen exerts immunomodulatory effects on human PBMCs
2024, Journal of Allergy and Clinical Immunology: GlobalDifferentiating asthma phenotypes in young adults through polyclonal cytokine profiles
2014, Annals of Allergy, Asthma and ImmunologyCitation Excerpt :However, it is well recognized that such biomarkers of atopic asthma are not universally associated with all asthma phenotypes and cytokine profiles more closely reflect the biomarkers vs clinical expression of disease.35 The importance of accounting for heterogeneity in the pathogenesis of different asthma phenotypes and the unexpected associations of TH1 cytokines to some forms of asthma have been more recently emphasized.2,36,37 The present data not only extend observations of the absence of TH2-skewed immunity in nonallergic asthma but also suggest TH1-polarized responses in these patients compared with those without a diagnosis of asthma.
Parental characteristics, somatic fetal growth, and season of birth influence innate and adaptive cord blood cytokine responses
2009, Journal of Allergy and Clinical ImmunologyCitation Excerpt :IFN-γ responses also showed a clear seasonal pattern across multiple adaptive stimuli. Considering reports of delayed production of this cytokine in infants and preschoolers with recurrent wheezing episodes, this finding may be of special importance.4,37-40 Season of birth has indeed been studied as a risk factor for allergy and asthma, but primarily as an opportunity for concurrent postnatal viral infections, allergen exposures, and sensitization of the newborn and infant related to the time of year.16,41-46
Nonlinear relationship of mite allergen exposure to mite sensitization and asthma in a birth cohort
2008, Journal of Allergy and Clinical ImmunologyPlasma UGRP1 levels associate with promoter G-112A polymorphism and the severity of asthma
2008, Allergology InternationalEffect of bacterial endotoxin LPS on expression of INF-γ and IL-5 in T-lymphocytes from asthmatics
2007, Clinical ImmunologyCitation Excerpt :It has been suggested that pathogens or their products elicit TH1 immune responses, which down-regulate the TH2 cells, a hallmark of allergic asthma. However, recent studies suggest that a simple change in the ratio of TH1 and TH2 cytokines does not account for the ability of pathogens to protect against the progression of asthma [16,17]. The T helper type 1 (TH1)/TH2 paradigm was initially proposed as the immunological concept underlying the hygiene hypothesis.