Pathogenesis of “fibrosis” in interstitial pneumonia: An electron microscopic study
References (32)
- et al.
Pulmonary interstitial edema and hyaline membranes in adult burn patients. Electron microscopic observations
Hum Pathol
(1974) - et al.
Response of the lower respiratory tract to injury. Mechanisms of repair of the parenchymal cells of the alveolar wall
Chest
(1983) - et al.
Another look at ARDS
Chest
(1982) - et al.
Basic pattern of tissue repair in human lungs following unspecific injury
Chest
(1974) - et al.
Fine structural morphometry on biopsy specimens of human lung. 2. Diffuse idiopathic pulmonary fibrosis
Chest
(1974) - et al.
Oxygen pneumonitis in man. Light and electron microscopic morphometric studies
Chest
(1972) - et al.
Interstitial lung disease of unknown cause. Disorders characterized by chronic inflammation of the lower respiratory tract
N Engl J Med
(1984) - et al.
Idiopathic pulmonary fibrosis. Clinical, histologic, radiographic, physiologic, scintigraphic, cytologic, and biochemical aspects
Ann Intern Med
(1976) Definition and classification of interstitial pneumonias in human pathology
Prog Respir Res
(1975)- et al.
Rapidly fatal pulmonary fibrosis: the accelerated variant of interstitial pneumonitis
Thorax
(1979)
Acute diffuse interstitial fibrosis of the lungs
Bull Johns Hopkins Hosp
Diffuse alveolar damage. The role of oxygen, shock, and related factors
Am J Pathol
Collagen concentration and rates of synthesis in idiopathic pulmonary fibrosis
Am Rev Respir Dis
Alterations of the gas exchange apparatus in adult respiratory insufficiency associated with septicemia
Am Rev Respir Dis
Cited by (132)
Loss of IGFBP2 mediates alveolar type 2 cell senescence and promotes lung fibrosis
2023, Cell Reports MedicinePathogenesis, Imaging, and Evolution of Acute Lung Injury
2022, Radiologic Clinics of North AmericaCitation Excerpt :If the patient survives, much of the ALI can resolve, although worsening fibrosis is often seen.1 Basement membrane damage is a common finding at electron microscopy in patients with UIP even in the absence of an acute exacerbation.9,38,44 The relationship between UIP and the organization that occurs in response to acute or subacute lung injury is not entirely understood.
Patient-specific iPSCs carrying an SFTPC mutation reveal the intrinsic alveolar epithelial dysfunction at the inception of interstitial lung disease
2021, Cell ReportsCitation Excerpt :With the advent of genome-wide association studies and intensive study of familial forms of pulmonary fibrosis, the lung epithelium has been increasingly implicated as a potential proximal disease driver with variants in gene loci expressed in lung epithelia having been associated with disease risk (Garcia, 2018; Kropski et al., 2015). Of the many types of epithelia present in the lung, dysfunction of the alveolar epithelial type 2 cell (AEC2), in particular, has been repeatedly implicated in the pathogenesis of interstitial lung disease (ILD), including IPF (Barkauskas and Noble, 2014; Katzenstein, 1985; Winters et al., 2019; Selman and Pardo, 2014). Determining how AEC2 dysfunction leads to disease in humans, however, has been challenging to date.
Interstitial Lung Disease in 2020: A History of Progress
2021, Clinics in Chest MedicineInteraction Between Epithelial and Mesenchymal Cells in Interstitial Lung Disease
2021, Encyclopedia of Respiratory Medicine, Second Edition
- 1
Received from the Department of Pathology, University of Alabama at Birmingham.