Original articleSerum angiotensin-converting enzyme activity in normal children and in those with sarcoidosis*
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Cited by (83)
Immune response to SARS-CoV-2 variants: A focus on severity, susceptibility, and preexisting immunity
2022, Journal of Infection and Public HealthCurrent scenario of COVID-19 in pediatric age group and physiology of immune and thymus response
2020, Saudi Journal of Biological SciencesCitation Excerpt :While adolescents had higher concentrations of blood ACE than adults and is interesting to observe that COVID-19 in the age group 10–19 years is only found in 1% in the Chinese group. Epidemiological proofs show that SARS-CoV-2 in children is less intense than adults (Rodriguez et al., 1981; Skarstein, 2020; Wan et al., 2020) One of the most common parameters for the severity of the COVID-19 is the chronic illness, like high blood pressure, diabetes, and cardiovascular disease (Mizumoto et al., 2015).
Serial investigation of Angiotensin-Converting Enzyme in sarcoidosis patients treated with Angiotensin-Converting Enzyme Inhibitor
2020, European Journal of Internal MedicineCitation Excerpt :It is elevated in serum and BAL of sarcoidosis patients and its concentrations are correlated with radiological stages [11, 12]. The International Guidelines for the diagnosis of sarcoidosis proposed ACE as a diagnostic and prognostic marker, however its sensitivity (41.4%, 95% CI 35.3-47.8%) [11] and specificity are poor (false positives are frequent and about 50% of sarcoidosis patients have normal levels of this protein at onset) [13, 14]. ACE may be elevated in certain granulomatous disorders (e.g. tuberculosis, berylliosis, silicosis).
ACE2, COVID19 and serum ACE as a possible biomarker to predict severity of disease
2020, Journal of Clinical VirologySerum Angiotensin-Converting Enzyme Has a High Negative Predictive Value in the Investigation for Systemic Sarcoidosis
2018, American Journal of OphthalmologyCitation Excerpt :Serum ACE performed less well as a screening test in the pediatric population, with high false positives; however, it still had a high NPV in this cohort. ACE levels are higher in normal children compared to adults, with 1 study reporting a mean of 32.1 ± 8.5 in adults and 46.7 in children,22 and within our study, ACE levels were 44% higher in normal children compared to adult values. Rodriguez and associates observed elevated ACE in 40% of normal children, compared to 80% of children with systemic sarcoidosis.22
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Presented in part at the Annual Meetings of the American Academy of Allergy, New Orleans, March, 1979, and of the Society of Pediatric Research, Atlanta, May, 1979.
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Recipient of an American Lung Association training fellowship (1979–1980).