Elsevier

Cytokine

Volume 3, Issue 3, May 1991, Pages 189-194
Cytokine

Original contribution
Hypoxia increases production of interleukin-1 and tumor necrosis factor by human mononuclear cells

https://doi.org/10.1016/1043-4666(91)90015-6Get rights and content

Abstract

Exposure to hypoxia (PO2 = 9 ± 1 torr) increased human peripheral blood mononuclear cell production and secretion of interleukin-1 (IL-1)α, IL-1β, and tumor necrosis factor (TNF) (percent of control = 190% for IL-1α, p = 0.014; 219% for IL-1β, p = 0.014; and 243% for TNF, p = 0.037) following treatment with endotoxin (1 ng/ml). Hypoxia potentiated the increased production of these inflammatory cytokines at subthreshold levels of endotoxin with potentiation increasing at lower O2 concentrations. Hypoxia also increased cytokine production induced by the tumor promoter phorbol myristate acetate, suggesting a generalized biologic response. We conclude that hypoxia increases IL-1 and TNF production and speculate that this mechanism aggravates a variety of pathologic conditions involving endotoxin such as adult respiratory distress syndrome (ARDS), multiple organ failure, and septic shock.

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