Control of scarring in adult wounds by neutralising antibody to transforming growth factor β

doi:10.1016/0140-6736(92)90009-R

The Lancet

Volume 339, Issue 8787, 25 January 1992, Pages 213-214

https://doi.org/10.1016/0140-6736(92)90009-R Get rights and content

Abstract

Adult wounds heal with scar-tissue formation, whereas fetal wounds heal without scarring and with a lesser inflammatory and cytokine response. We injected the margins of healing dermal wounds in adult rats with neutralising antibody (NA) to transforming growth factor-β (TGF-β). All control wounds (irrelevant antibody, or TGF-β, or no injection) healed with scarring, whereas the NA-treated wounds healed without scar-tissue formation; NA-treated wounds had fewer macrophages and blood vessels, lower collagen and fibronectin contents, but identical tensile strength and more normal dermal architecture than the other wounds. Early manipulation of the concentrations of selected cytokines may be a new approach to the control of Scarring.

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Citation Excerpt :
The increased or prolonged activity of TGF-β1 leads to overproduction and excess deposition of collagen by fibroblasts, often resulting in HTS [105]. Inhibition of TGF-β1 and TGF-β2 results in improved orientation of ECM in the wound and less scarring in a rat incisional model [106]. Downregulation of TGF-β1 receptor expression in the late proliferative and early remodeling phases of wound healing reduces CTGF and ECM deposition in scar tissue [107].
While wound therapy remains a clinical challenge in current medical practice, much effort has focused on developing biological therapeutic approaches. This paper presents a comprehensive review of delivery systems for current biologicals for the treatment of chronic wounds and severe burns. The biologicals discussed here include proteins such as growth factors and gene modifying molecules, which may be delivered to wounds free, encapsulated, or released from living systems (cells, skin grafts or skin equivalents) or biomaterials. Advances in biomaterial science and technologies have enabled the synthesis of delivery systems such as scaffolds, hydrogels and nanoparticles, designed to not only allow spatially and temporally controlled release of biologicals, but to also emulate the natural extracellular matrix microenvironment. These technologies represent an attractive field for regenerative wound therapy, by offering more personalised and effective treatments.

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SHORT REPORTSControl of scarring in adult wounds by neutralising antibody to transforming growth factor β

Abstract

Dev Biol

Clin Plast Surg

J Pediatr Surg

Annu Rep Med Chem

The extracellular matrix of lip wounds in fetal, neonatal and adult mice

Development

SHORT REPORTS
Control of scarring in adult wounds by neutralising antibody to transforming growth factor β