SHORT REPORTSImmunogenetic prediction of pulmonary fibrosis in systemic sclerosis
References (9)
- et al.
Scleroderma (systemic sclerosis): classification, subsets, and pathogenesis
J Rheumatol
(1982) - et al.
Histocompatibility antigens in progressive systemic sclerosis (scleroderma)
J Clin Immunol
(1982) - et al.
Clinical correlations and prognosis based on serum autoantibodies in patients with systemic sclerosis
Arthritis Rheum
(1988) - et al.
Cryptogenic fibrosing alveolitis: clinical features and their influence on survival
Thorax
(1980)
Cited by (127)
Bi-directional communication: Conversations between fibroblasts and immune cells in systemic sclerosis
2020, Journal of AutoimmunityCitation Excerpt :Inflammatory infiltrate in the SSc lung consists predominantly of infiltrating B cells [21]. The majority of patients with SSc-associated ILD are positive for anti-nuclear antibodies (ANAs) that are frequently accompanied by anti-Scl-70, anti-topoisomerase-1 antibodies or anti-fibroblast antibodies [22–24]. Anti-centromere antibodies are more commonly found in patients with the limited form of disease [25].
Autoimmune Biomarkers, Antibodies, and Immunologic Evaluation of the Patient with Fibrotic Lung Disease
2019, Clinics in Chest MedicineCitation Excerpt :Anti-Scl70 antibodies have been associated with diffuse cutaneous form, disease activity, increased risk of pulmonary fibrosis, and worse clinical outcomes. More than 85% of Scl-70 antibody-positive SSc patients will eventually develop pulmonary fibrosis68 with a sensitivity and specificity for the prediction of ILD of 45% and 81%, respectively.69 Among anti-Scl70(+) SSc patients, African Americans present with more advanced fibrotic lung disease and worse survival compared with Caucasians.70
Translational research in pulmonary fibrosis
2019, Translational ResearchCitation Excerpt :It is diagnosed through the detection of antinuclear antibodies in the serum (anti-RNA polymerase, anticentromere, antitopoisomerase [ATA]), each of which correspond to clinical subsets of disease. ATA, for instance, is also frequently called “anti-Scl-70”: patients with this phenotype are prone to lung fibrosis.17 Different pathologic findings are observed in SSc-ILD: most commonly nonspecific interstitial pneumonia (77.5% in one observational study), though usual interstitial pneumonia (UIP), a specific pattern of fibrosis characteristic of IPF and associated with poor prognosis, is not uncommonly observed (15%).18
Genetic determinants of interstitial lung diseases
2019, Emery and Rimoin's Principles and Practice of Medical Genetics and Genomics: Cardiovascular, Respiratory, and Gastrointestinal DisordersInterstitial Lung Disease in the Connective Tissue Diseases
2018, Interstitial Lung Disease