Association of sleep apnoea with myocardial infarction in men

doi:10.1016/0140-6736(90)91799-G

The Lancet

Volume 336, Issue 8710, 4 August 1990, Pages 261-264

https://doi.org/10.1016/0140-6736(90)91799-G Get rights and content

Abstract

To examine the hypothesis that sleep apnoea is a risk factor for ischaemic heart disease, overnight polysomnography was performed in 101 unselected male survivors of acute myocardial infarction (MI) aged < 66 yr and in 53 male subjects of similar age without evidence of ischaemic heart disease. The apnoea index (Al, number of apnoea episodes per hour of sleep) was 6·9 (SEM 1·2) in the Ml patients versus 1·4 (0·3) in the control subjects. After adjustment for age, body mass index, hypertension, smoking, and cholesterol level, multiple logistic regression analysis identified the top quartile of Al (>5·3) as an independent predictor of MI patients. The relative risk for myocardial infarction between the highest and lowest quartiles of Al was 23·3 (95% confidence interval 3·9-139·9).

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Citation Excerpt :
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This study investigated whether intermittent hypoxia (IH) induces airway hyperresponsiveness (AHR) and associated with lung inflammation. Male Brown Norway rats were exposed to 14-day IH or room air (RA) for 6 h/day. One day after the last exposure, total lung resistance to various doses of methacholine was measured as an index of bronchoconstrictive responses. Compared with RA controls, methacholine significantly induced an augmented bronchoconstriction in IH-exposed rats. Moreover, IH exposure evoked lung inflammation which was reflected by increased inflammatory cell infiltration, concentrations of interleukin-6 and prostaglandin E₂ in bronchoalveolar lavage fluid, and lung lipid peroxidation. IH-induced AHR and lung inflammation were completely abolished by daily intraperitoneal injection of N-acetylcysteine (an antioxidant) or ibuprofen (a cyclooxygenase inhibitor), but not by apocynin (an inhibitor of NADPH oxidase) or vehicle. In conclusion, AHR and lung inflammation occur after 14-day IH exposure, with endogenous reactive oxygen species and cyclooxygenase metabolites being responsible for these responses.

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MEDICAL SCIENCEAssociation of sleep apnoea with myocardial infarction in men

Abstract

Lancet

Lancet

Chest

Am Heart J

Atherosclerosis

Chest

Chest

Am J Cardiol

Am Heart J

Lancet

Snoring as a risk factor for disease: an epidemiological survey

Br Med J

Snoring as a risk factor for ischaemic heart disease and stroke in men

Br Med J

Excessive daytime sleepiness: a 1-year study of an unselected inpatient population

Sleep

Incidence of sleep apnea in a presumably healthy working population: a significant relationship with excessive daytime sleepiness

Sleep

Prevalence of sleep apnea syndrome among Swedish men—an epidemiological study

J Clin Epidemiol

MEDICAL SCIENCE
Association of sleep apnoea with myocardial infarction in men