The low prevalence of occupational asthma and antibody-dependent sensitization to diphenylmethane diisocyanate in a plant engineered for minimal exposure to diisocyanates
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Trimellitic anhydride facilitates transepithelial permeability disrupting tight junctions in sinonasal epithelial cells
2021, Toxicology LettersCitation Excerpt :In contrast to immunologic OR, non-immunologic OR mainly involves exposure to LMW agents and its pathophysiology is unclear. Several different LMW agents have been implicated in the development of OR including acid anhydride, diisocyanates, ammonium persulphate and platinum (Baker et al., 1990; Bernstein et al., 1993; Diab et al., 2009; Lysdal et al., 2014; Sastre et al., 2014; Zeiss et al., 1977). Acid anhydrides such as trimellitic anhydride (TMA) are common chemical agents utilized in the production of paints, vinyl plasticizers and epoxy resins as hardening agents.
Occupational exposure and asthma
2018, Annals of Allergy, Asthma and ImmunologyOccupational Rhinitis
2016, Immunology and Allergy Clinics of North AmericaThresholds in chemical respiratory sensitisation
2015, ToxicologyManagement of the individual worker with occupational asthma
2013, Annals of Allergy, Asthma and ImmunologyCitation Excerpt :As already mentioned, once a worker develops OA, chemical exposure cannot be realistically prevented to the degree required to avert work-related asthma symptoms. Therefore, prompt recognition of OA and immediate cessation from work-related exposure to chemical (or protein) sensitizers should be strongly recommended to the worker and employer and can be justified by published evidence indicating that early intervention may result in complete remission or cure of asthma.17 The recommended approach, however, differs with respect to environmental interventions for workers with irritant-induced OA (eg, acute irritant-induced asthma).