Hypoxic vasoconstriction in buffer-perfused rabbit lungs
References (24)
- et al.
The role of lung perfusate PO2 in the control of the pulmonary vascular resistance of exteriorized fetal lambs
Respir. Physiol.
(1990) - et al.
Hypoxic vasoconstriction in blood and plasma perfused lungs
Respir. Physiol.
(1988) - et al.
Time course of pulmonary vasoconstriction with repeated hypoxia and glucose depletion
Respir. Physiol.
(1986) - et al.
Adult respiratory distress syndrome: model systems using isolated perfused rabbit lungs
Methods Enzymol.
(1994) Site of hypoxic pulmonary vasoconstriction
Chest
(1985)- et al.
Determination of the sensitive vascular sites from which hypoxia and hypercapnia elicit rises in pulmonary arterial pressure
Hypoxia on the pulmonary circulation
How and where it acts
Circ. Res.
(1976)- et al.
Effects of perfusate composition on hypoxic vasoconstriction in isolated lung lobes
J. Appl. Physiol.
(1967) - et al.
Hypoxic pulmonary vasoconstriction during steady and pulsatile flow in ferrets
J. Appl. Physiol.
(1984) Conditions governing the pressor response to ventilation hypoxia in isolated perfused rat lungs
Acta Physiol. Scand.
(1968)
Hypoxia and pulmonary vascular resistance
The relative effects of pulmonary arterial and alveolar PO2
Acta Physiol. Scand.
Rapid onset of hypoxic vasoconstriction in isolated lungs
J. Appl. Physiol.
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Mitochondrial oxygen sensing of acute hypoxia in specialized cells - Is there a unifying mechanism?
2022, Biochimica et Biophysica Acta - BioenergeticsCitation Excerpt :HPV is initiated at mild hypoxia and shows specific dynamic features. In investigations in the model of the isolated, buffer-perfused and ventilated rabbit lung, HPV was detected at a pO2 below 40–75 mmHg in the ventilated gas [11], and in PASMC at a pO2 of 25–50 mmHg in the buffer [7,8]. In humans, HPV was detected at an end-expiratory pO2 of 50 mmHg [23].
Hypoxia and the integrated stress response promote pulmonary hypertension and preeclampsia: Implications in drug development
2021, Drug Discovery TodayCitation Excerpt :Both are low-pressure, high-flow systems [5,6]. Upon exposure to acute hypoxia, systemic arteries and arterioles dilate, whereas pulmonary and uteroplacental arteries and arterioles constrict, leading to increased vascular resistance and reduced blood flow [7,8]. Pulmonary hypertension is a disorder of pulmonary arteries, characterized by a mean pulmonary arterial pressure ≥ 20 mm Hg [9].
Hypoxia induces K <inf>v</inf> channel current inhibition by increased NADPH oxidase-derived reactive oxygen species
2012, Free Radical Biology and MedicineCitation Excerpt :The unique feature of pulmonary circulation is its ability to contract in response to hypoxia. This ability of the lung vasculature helps in minimizing ventilation perfusion mismatch by diverting blood flow from poorly to well ventilated regions of the lung [1,2]. This phenomenon is known as hypoxic pulmonary vasoconstriction (HPV) [3].
Hypoxia-induced changes in pulmonary and systemic vascular resistance: Where is the O<inf>2</inf> sensor?
2010, Respiratory Physiology and NeurobiologyCitation Excerpt :A large number of studies have examined the responses to hypoxia in the pulmonary and systemic circulations. In the lung, the HPV response is retained in excised lungs, in lung slices, and in PA rings studied in an organ bath (Archer et al., 1993; Desireddi et al., 2010; Grimminger et al., 1995; Leach et al., 2001; Marshall et al., 1996; McMurtry, 1984; Robertson et al., 2001; Rounds and McMurtry, 1981; Weissmann et al., 1998, 1995; Zhao et al., 1996). Isolated PA smooth muscle cells (PASMC) also contract under hypoxia, indicating that these cells are O2-sensitive (Lu et al., 2009; Shimoda et al., 2007; Waypa et al., 2001, 2002, 2006, 2010; Zhang et al., 1997).
Redox signaling and reactive oxygen species in hypoxic pulmonary vasoconstriction
2010, Respiratory Physiology and NeurobiologyThe Pulmonary Vasculature
2023, Seminars in Respiratory and Critical Care Medicine
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Portion of a doctoral thesis at the University of Giessen.