Predicted gas exchange on the summit of Mt. Everest
References (27)
Calculation of certain indices of cardio-pulmonary function using a digital computer
Respir. Physiol.
(1966)- et al.
Reduction of stroke volume during exercice in man following ascent to 3,100 m altitude
J. Appl. Physiol.
(1967) - et al.
Physiological deadspace and alveolar gas pressures at rest and during muscular exercise
Acta Physiol. Scand.
(1956) Limiting factors to oxygen transport on Mount Everest
J. Appl. Physiol.
(1976)Regional lung function during early acclimatization to 3,100 m altitude
J. Appl. Physiol.
(1972)L'Everest sans oxygène: le problème respiratoire
J. Physiol. (Paris)
(1979)Lactic acid and rest and work at high altitudes
Am. J. Physiol.
(1936)- et al.
Alveolar gas composition at 21,000 to 25,700 feet
J. Physiol. (London)
(1962) - et al.
The regulation of the lung-ventilation
J. Physiol. (London)
(1905) - et al.
Pulmonary capillary blood volume, flow and diffusing capacity during exercise
J. Appl. Physiol.
(1960)
Pulmonary diffusion factors as a limiting factor in exercise stress
Circ. Res.
Digital computer subroutine for the conversion of oxygen tension into saturation.
J. Appl. Physiol.
Digital computer procedures for the conversion of PCO2 into blood CO2 content
Respir. Physiol.
Cited by (72)
Altitude acclimatization, hemoglobin-oxygen affinity, and circulatory oxygen transport in hypoxia
2022, Molecular Aspects of MedicineHow important is V̇O<inf>2</inf>max when climbing Mt. Everest (8,849 m)?
2022, Respiratory Physiology and NeurobiologyCitation Excerpt :Such V̇O2max levels are barely larger than V̇O2 needed during resting conditions at sea level (about 3.5 mL/min/kg), absolutely not compatible with climbing activities close to the summit of Everest. Those calculations were based on an average sea level V̇O2max of about 50 mL/min/kg (Pugh et al., 1964; West and Wagner, 1980). West and Wagner highlighted the critical importance of only small changes in barometric pressure and associated diffusion limitation of oxygen transfer by the blood-gas barrier in those extreme hypoxic conditions, likely explaining the unexpected success of Messner and Habeler (West and Wagner, 1980).
Into Thick(er) Air? Oxygen Availability at Humans' Physiological Frontier on Mount Everest
2020, iScienceCitation Excerpt :Air pressure is relatively high on Mt. Everest because the rate at which pressure falls with elevation is inversely proportional to the virtual temperature of the atmosphere (Stull, 2015), and Mt. Everest is, along with all other peaks over 8,000 m, located in the warmth of the subtropics. Oxygenless ascents of Earth's highest mountains would be an even greater demand for human physiology if they were located in colder climates (West, 1993, 2010; West and Wagner, 1980). There is also a temporal equivalent of this geographical good fortune that helps place Mt. Everest's summit within reach.
The O<inf>2</inf> and CO<inf>2</inf> Transport System in Teleosts and the Specialized Mechanisms That Enhance Hb–O<inf>2</inf> Unloading to Tissues
2017, Fish PhysiologyCitation Excerpt :However, the concept of optimality is a powerful tool for developing hypotheses and fits well within the comparative approach, as long as the adaptive value of the results is not overinterpreted or indiscriminately translated in vivo (for reviews see Dudley and Gans, 1991; Wells, 1990). A number of excellent studies have addressed the idea of an optimal P50 in mammals (Tenney, 1995; Turek et al., 1973; West and Wagner, 1980; Willford et al., 1982) and in fishes (Brauner and Wang, 1997; Wang and Malte, 2011), and the analysis provided here is a synthesis of previous findings. Both equations will return the same optimal P50 value, whether P50 is defined in terms of maximal Sa–vO2 or PvO2.
Gas Exchange at Rest and during Exercise in Mammals
2015, Comparative Biology of the Normal Lung: Second Edition