Clinical studyCaffeine and hypertension☆
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Cited by (71)
The effects of caffeine supplementation on blood pressure in adults: A systematic review and dose-response meta-analysis
2023, Clinical Nutrition ESPENA short-term effect of caffeinated beverages on blood pressure: A meta-analysis of randomized controlled trails
2021, Journal of Functional FoodsEvaluation of caffeine versus codeine for pain and swelling management after implant surgeries: A triple blind clinical trial
2017, Journal of Cranio-Maxillofacial SurgeryCitation Excerpt :This process would increase the release of catecholamines and stimulate the renin-angiotensin-aldosterone axis. Published articles support this idea of the vasoconstrictor nature of caffeine resulting in a significant decrease in inflammation compared with codeine (Chaturvedi et al., 2009; Baratloo et al., 2016a,b; Echeverri et al., 2010; Robertson et al., 1978, 1984). The severity of inflammation after oral surgeries, especially in the absence of an infectious process, decreases on the third day until the first week postoperatively (Raisian et al., 2012; Pasqualini et al., 2005; Costa et al., 2015; Pouchain et al., 2015).
Caffeine and cardiovascular health
2017, Regulatory Toxicology and PharmacologyCitation Excerpt :Most studies considered exposures ranging from approximately 100 to 400 mg per day (or exposure/dose period). There were 111 controlled-exposure studies with fixed dose(s) of caffeine administered often via a pill or suspension to subjects, followed by the monitoring of blood pressure changes over the course of a few hours or one day (Addicott et al., 2009; Ammar et al., 2001; Ammon et al., 1983; Arciero et al., 1998, Arciero and Ormsbee, 2009; Astorino et al., 2007; Astorino et al., 2013; Awaad et al., 2011; Bak and Grobbee, 1990, 1991; Barry et al., 2005; Benowitz et al., 1995; Berry et al., 2003; Blaha et al., 2007; Burr et al., 1989; Buscemi et al. 2009, 2010; Cavalcante et al., 2000; Chen and Parrrish, 2009; Childs and de Wit, 2006; Daniels et al., 1998; Del Cosco et al., 2012; Eggertsen et al., 1993; Engels et al., 1999; Farag et al. 2005a, 2005b, 2006, 2010; Fernandez-Elias et al., 2015; Franks et al., 2012; Funatsu et al., 2005; Grasser et al., 2014, 2015; Hamer et al., 2006; Hartley et al., 2000, 2004; Hodgson et al., 1999; Hodgson et al., 2005; Hoffman et al., 2006; Humayun et al., 1997; James, 1994a, 1994b; James and Gregg, 2004; Kaminsky et al., 1998; Karatzis et al., 2005; Kennedy et al., 2008; Kurtz et al., 2013; Lane et al., 1998, 2002; Lemery et al., 2015; Lovallo et al., 1996, 2004; Mahmud and Feely, 2001; Miles-Chan et al., 2015; Mosqueda-Garcia et al., 1990; Noguchi et al., 2015; Notarius et al., 2006a, 2006b; Nussberger et al., 1990; Papaioannou et al., 2006; Papamichael et al., 2005; Passmore et al., 1987; Phan and Shah, 2014; Pincomb et al., 1996; Rachima-Maoz et al., 1998; Ragab et al., 2004; Ragsdale et al., 2010; Rakic et al., 1999; Rashti et al., 2009; Roberts et al., 2005; Robertson et al., 1978, 1981, 1984; Savoca et al., 2004, 2005; Shepard et al., 2000; Sondermeijer et al., 2002; Souza et al., 2014; Steinke et al., 2009; Strandhagen and Thelle, 2003; Stubbs and Macdonald, 1995; Sudano et al., 2005; Sung et al. 1994, 1995; Swampillai et al., 2006; Temple et al., 2010; Terai et al., 2012; Tse et al., 2009; Turley and Gerst, 2006; Turley et al., 2007, 2008; Ulanovsky et al., 2014; Umemura et al., 2006; van Dusseldorp et al., 1991; van Dusseldorp et al., 1989; Vlachopoulos et al., 2003b; Waring et al., 2003; Watson et al., 2000, 2002; Zimmermann-Viehoff et al., 2016; Agudelo-Ochoa et al., 2016; Brothers et al., 2016; Doerner et al., 2015; Domotor et al., 2015; Garcia et al., 2016; Hajsadeghi et al., 2016; Molnar and Somberg, 2015a; Papakonstantinou et al., 2016; Peveler et al., 2016; Shah et al., 2016; Teng et al., 2016). In 19 observational studies, individuals’ blood pressures were measured after ascertaining their average daily coffee and/or tea intake (Bakker et al., 2011; Bertrand et al., 1978; Chen et al., 2010; Giggey et al., 2011; Guessous et al., 2012; Hart and Smith, 1997; Larsson et al., 2008; Palatini et al., 1996; Reis et al., 2010; Stensvold et al., 1989; Vlachopoulos et al. 2005, 2007; Wakabayashi et al., 1998; Wang et al., 2011; Wilhelmsen et al., 1977; Wilson et al., 1989; Lopez-Garcia et al., 2016; Palatini et al., 2016; Rhee et al., 2016).
Polymorphism and disorder in natural active ingredients. Low and high-temperature phases of anhydrous caffeine: Spectroscopic (<sup>1</sup>H-<sup>14</sup>N NMR-NQR/<sup>14</sup>N NQR) and solid-state computational modelling (DFT/QTAIM/RDS) study
2016, European Journal of Pharmaceutical SciencesCitation Excerpt :In this paper we report a study on polymorphism of anhydrous caffeine (1,3,7-trimethylxanthine; 1,3,7-trimethyl-1H-purine-2,6-(3H,7H)-dione), Fig. 1, a widely used stimulant but also NAI, which reveals a multifaceted therapeutic potential on the human organism. Caffeine affects fundamental processes such as sleep, arousal, cognition, learning and memory and is able to stimulate central nervous system, as well as muscular, respiratory and circular systems (Grobbee et al., 1990; Jee et al., 1999; Robertson et al., 1984; Nurminen et al., 1999). It has the ability to reduce the physical, cellular and molecular damage caused by spinal cord injury (SCI), stroke (cerebral infarction) or neurodegenerative chronic diseases including diabetes II as well as Parkinson (Ross et al., 2000; Postuma et al., 2012; Popat et al., 2011) and Alzheimer's diseases (Eskelinen and Kivipelto, 2010; Maia and Mendonca, 2002; Biessels, 2010; Chen and Chern, 2011), whose development it also inhibits.
Effects of coffee on type 2 diabetes mellitus
2014, NutritionCitation Excerpt :It contains several substances that may affect glucose uptake and metabolism and is obtained from tealeaves, guarana, and cola plant seeds [1]. Numerous epidemiologic, clinical, experimental, or a combination of all three, studies have been conducted to investigate the effects of coffee on cardiovascular diseases [2,3], cancers [4], cholelithiasis [5], neurologic disorders [6], endocrine disorders [7–9], kidney stones, [10] and T2DM [11–13]. Diabetes mellitus is an autoinflammatory syndrome that is a collection of many disorders such as hyperglycemia, dyslipidemia, insulin resistance, impaired β-cell functioning, and insulin secretion [14–17].
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This work was supported in part by National Institutes of Health Grants HL-14192 and GM-31304, and by grants from the Hrafn Sveinbjarnarson Foundation and the International Life Sciences Institute.
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Dr. Robertson is the recipient of a Research Career Development Award (1 K04 GM00494) from the National Institutes of Health.
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From the Departments of Medicine and Pharmacology, Divisions of Clinical Pharmacology and Endocrinology, Specialized Center of Research in Hypertension, Vanderbilt University, Nashville, Tennessee.