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Expression of Profi brotic Growth Factors and Their Receptors by Mouse Lung Macrophages and Fibroblasts under Conditions of Acute Viral Infl ammation in Infl uenza A/H5N1 Virus

  • VIROLOGY
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Bulletin of Experimental Biology and Medicine Aims and scope

Morphological signs of early interstitial fi brosis, developing under conditions of acute viral inflammation (postinfection days 1-14), were observed in C57Bl/6 mice infected with influenza A/H5N1 A/goose/Krasnoozerskoye/627/05 virus. The development of fi brosis was confirmed by an increase in the number of lung cells expressing TNF-α. These changes were recorded in the presence of a many-fold increase in the counts of macrophages and fi broblasts expressing FGF, EGF, and their receptors.

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Authors and Affiliations

  1. Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia

    A. G. Anikina, V. A. Shkurupii, O. V. Potapova, A. V. Kovner & A. M. Shestopalov

  2. Novosibirsk State Medical University, Ministry of Health of the Russian Federation, Novosibirsk, Russia

    A. G. Anikina & V. A. Shkurupii

Authors
  1. A. G. Anikina
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  2. V. A. Shkurupii
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  3. O. V. Potapova
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  4. A. V. Kovner
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  5. A. M. Shestopalov
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Corresponding author

Correspondence to O. V. Potapova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 156, No. 12, pp. 803-807, December, 2013

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Anikina, A.G., Shkurupii, V.A., Potapova, O.V. et al. Expression of Profi brotic Growth Factors and Their Receptors by Mouse Lung Macrophages and Fibroblasts under Conditions of Acute Viral Infl ammation in Infl uenza A/H5N1 Virus. Bull Exp Biol Med 156, 833–837 (2014). https://doi.org/10.1007/s10517-014-2463-7

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  • DOI: https://doi.org/10.1007/s10517-014-2463-7

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