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Addition of a macrolide to a ß-lactam in bacteremic pneumococcal pneumonia

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Abstract

In the study presented here, data collected prospectively from 340 adult patients hospitalised in five countries with bacteremic pneumococcal CAP and treated with a ß-lactam +/− a macrolide were analysed retrospectively to evaluate the efficacy of this antimicrobial combination. Univariate and multivariate analyses revealed no significant effect on case fatality rate when a macrolide/ß-lactam regimen was used as initial therapy. Results were not affected by severity of illness, or by excluding patients who died within 2 days of admission. Identified predictors of death in a multivariate regression model were age >65 years (OR=2.6), two or more lung lobes affected (OR=2.2), and severity of disease as estimated using the acute physiology score (APS)>8.

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Authors and Affiliations

  1. Department of Medicine, Infectious Disease Unit, Karolinska University Hospital, 14186, Stockholm, Sweden

    R. Dwyer, Å. Örtqvist, E. Aufwerber, M. Ålenius & M. Kalin

  2. Department of Molecular Epidemiology and Biotechnology, Swedish Institute for Infectious Disease Control, Stockholm, Sweden

    B. Henriques Normark

  3. 2J2.00 Walter C. Mackenzie Health Sciences Centre, 8440 112th Street, Edmonton, Alberta, 6 27, Canada

    T.J. Marrie

  4. Department of Medicine, Marshall University, John C. Edwards School of Medicine, Huntington, WV, 25701-3655, USA

    M.A. Mufson

  5. Institut Clínic de Pneumologia i Cirurgia Toràcica, Hospital Clínic de Barcelona, C/Villarroel, 170, 08036, Barcelona, Spain

    A. Torres

  6. Department of Respiratory Medicine, Manchester Royal Infirmary, Oxford Road, Manchester, M13 9WL, UK

    M.A. Woodhead

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  1. R. Dwyer
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  2. Å. Örtqvist
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  3. E. Aufwerber
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  4. B. Henriques Normark
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  5. T.J. Marrie
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  6. M.A. Mufson
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  7. A. Torres
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  8. M.A. Woodhead
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  9. M. Ålenius
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  10. M. Kalin
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Correspondence to R. Dwyer.

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Dwyer, R., Örtqvist, Å., Aufwerber, E. et al. Addition of a macrolide to a ß-lactam in bacteremic pneumococcal pneumonia. Eur J Clin Microbiol Infect Dis 25, 518–521 (2006). https://doi.org/10.1007/s10096-006-0183-2

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  • DOI: https://doi.org/10.1007/s10096-006-0183-2

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