Abstract
A 4-year-old boy with cystic fibrosis developed hypertension, rapid weight gain and a moon face 2 weeks after starting a combined treatment of oral itraconazole and inhaled budesonide for a suspected allergic bronchopulmonary aspergillosis. Adrenal suppression was documented and found to persist 3 months after stopping this combined treatment. Conclusion:to the best of our knowledge, this is the first time that an iatrogenic Cushing syndrome in a young child with cystic fibrosis after such combined treatment is reported. The inhibition of cytochrome P4503A by intraconazole and a higher glucocorticoid tissue sensitivity is suggested as the underlying mechanism.
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Abbreviations
- ABPA :
-
allergic bronchopulmonary aspergillosis
- CF :
-
cystic fibrosis
- DHEAS :
-
dehydro-epiandrosterone sulphate
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De Wachter, E., Vanbesien, J., De Schutter, I. et al. Rapidly developing Cushing syndrome in a 4-year-old patient during combined treatment with itraconazole and inhaled budesonide. Eur J Pediatr 162, 488–489 (2003). https://doi.org/10.1007/s00431-003-1233-8
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DOI: https://doi.org/10.1007/s00431-003-1233-8