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Dietary and cancer–related behaviors of vitamin/mineral dietary supplement users in a large cohort of French women

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Summary

Background

Several epidemiological studies suggested an association between vitamin/mineral dietary supplement use and cancer risk. However, characteristics of supplement users may themselves be related to cancer risk, and therefore could confound such etiological studies. Very little is known about the characteristics of French supplement users.

Aim of the study

To identify cancer–related behaviors and dietary characteristics of vitamin/mineral supplement users in the E3N cohort of French women.

Methods

Data on supplement use and cancer–related and socio–demographic characteristics were collected by self–administered questionnaires completed by 83,058 women, 67,229 of whom also completed a food frequency questionnaire. Supplement users were compared to non–users by unconditional logistic regression.

Results

Vitamin/mineral supplement users were significantly older and leaner (odds ratio [OR] for BMI ≥ 30 vs. <18.5 kg/m2 = 0.35, 95% confidence interval [CI] 0.31–0.39), were less often current smokers, had a higher level of education and had more leisure physical activity. They used more phytooestrogen supplements (OR=3.95, 95 % CI 3.69–4.23), had more often a family history of breast cancer and had more often undergone cancer–screening. Users tended to have a healthier diet: less alcohol, more vegetables, fruit, dairy products, fish and soups. They had higher dietary intakes for most micro–nutrients, fiber and ω3 fatty acids, lower fat intake and either similar or lower prevalence of inadequate dietary intake for all relevant nutrients except magnesium.

Conclusions

To avoid major confounding, the lifestyle characteristics of supplement users should be considered in studies investigating the association between supplement use and cancer risk.

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References

  1. Patterson RE,White E, Kristal AR, et al. (1997) Vitamin supplements and cancer risk: the epidemiologic evidence. Cancer Causes Control 8:786–802

    Article  CAS  Google Scholar 

  2. Nissen SB, Tjonneland A, Stripp C, et al. (2003) Intake of vitamins A, C, and E from diet and supplements and breast cancer in postmenopausal women. Cancer Causes Control 14:695–704

    Article  Google Scholar 

  3. Rimm EB, Willett WC, Hu FB, et al. (1998) Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women. JAMA 279:359–364

    Article  CAS  Google Scholar 

  4. Bjelakovic G, Nikolova D, Simonetti RG, et al. (2004) Antioxidant supplements for prevention of gastrointestinal cancers: a systematic review and metaanalysis. Lancet 364:1219–1228

    Article  CAS  Google Scholar 

  5. White E, Patterson RE, Kristal AR, et al. (2004) Vitamin And Lifestyle cohort study: study design and characteristics of supplement users. Am J Epidemiol 159:83–93

    Article  Google Scholar 

  6. Patterson RE, Neuhouser ML,White E, et al. (1998) Cancer-related behavior of vitamin supplement users. Cancer Epidemiol Biomarkers Prev 7:79–81

    CAS  Google Scholar 

  7. Neuhouser ML, Kristal AR, Patterson RE, et al. (2001) Dietary supplement use in the Prostate Cancer Prevention Trial: implications for prevention trials. Nutr Cancer 39:12–18

    Article  CAS  Google Scholar 

  8. Hoggatt KJ, Bernstein L, Reynolds P, et al. (2002) Correlates of vitamin supplement use in the United States: data from the California Teachers Study cohort. Cancer Causes Control 13:735–740

    Article  CAS  Google Scholar 

  9. Kaufman DW, Kelly JP, Rosenberg L, et al. (2002) Recent patterns of medication use in the ambulatory adult population of the United States: the Slone survey. JAMA 287:337–344

    Article  Google Scholar 

  10. Rock CL, Newman V, Flatt SW, et al. (1997) Nutrient intakes from foods and dietary supplements in women at risk for breast cancer recurrence. The Women’s Healthy Eating and Living Study Group. Nutr Cancer 29:133–139

    Article  CAS  Google Scholar 

  11. Slesinski MJ, Subar AF, Kahle LL (1996) Dietary intake of fat, fiber and other nutrients is related to the use of vitamin and mineral supplements in the United States: the 1992 National Health Interview Survey. J Nutr 126:3001–3008

    CAS  Google Scholar 

  12. Ervin RB, Wright JD, Kennedy-Stephenson J (1999) Use of dietary supplements in the United States, 1988–1994. Vital Health Stat 11:1–14

    Google Scholar 

  13. Lyle BJ, Mares-Perlman JA, Klein BE, et al. (1998) Supplement users differ from nonusers in demographic, lifestyle, dietary and health characteristics. J Nutr 128:2355–2362

    CAS  Google Scholar 

  14. Houston DK, Johnson MA, Daniel TD, et al. (1997) Health and dietary characteristics of supplement users in an elderly population. Int J Vitam Nutr Res 67:183–191

    CAS  Google Scholar 

  15. Frank E, Bendich A, Denniston M (2000) Use of vitamin-mineral supplements by female physicians in the United States. Am J Clin Nutr 72:969–975

    CAS  Google Scholar 

  16. Millen AE, Dodd KW, Subar AF (2004) Use of vitamin, mineral, nonvitamin, and nonmineral supplements in the United States: The 1987:1992, and 2000 National Health Interview Survey results. J Am Diet Assoc 104:942–950

    Article  Google Scholar 

  17. Stang J, Story MT, Harnack L, et al. (2000) Relationships between vitamin and mineral supplement use, dietary intake, and dietary adequacy among adolescents. J Am Diet Assoc 100:905–910

    Article  CAS  Google Scholar 

  18. Dwyer JT, Garcea AO, Evans M, et al. (2001) Do adolescent vitamin-mineral supplement users have better nutrient intakes than nonusers? Observations from the CATCH tracking study. J Am Diet Assoc 101:1340–1346

    Article  CAS  Google Scholar 

  19. Shikany JM, Patterson RE, Agurs- Collins T, et al. (2003) Antioxidant supplement use in Women’s Health Initiative participants. Prev Med 36:379–387

    Article  Google Scholar 

  20. Foote JA, Murphy SP,Wilkens LR, et al. (2003) Factors associated with dietary supplement use among healthy adults of five ethnicities: the Multiethnic Cohort Study. Am J Epidemiol 157:888–897

    Article  Google Scholar 

  21. Harrison RA, Holt D, Pattison DJ, et al. (2004) Are those in need taking dietary supplements? A survey of 21923 adults. Br J Nutr 91:617–623

    Article  CAS  Google Scholar 

  22. Kirk SF,Cade JE, Barrett JH, et al. (1999) Diet and lifestyle characteristics associated with dietary supplement use in women. Public Health Nutr 2:69–73

    CAS  Google Scholar 

  23. Kiely M, Flynn A, Harrington KE, et al. (2001) The efficacy and safety of nutritional supplement use in a representative sample of adults in the North/South Ireland Food Consumption Survey. Public Health Nutr 4:1089–1097

    Article  CAS  Google Scholar 

  24. Dorant E, van den Brandt PA, Hamstra AM, et al. (1993) The use of vitamins, minerals and other dietary supplements in The Netherlands. Int J Vitam Nutr Res 63:4–10

    CAS  Google Scholar 

  25. Knudsen VK, Rasmussen LB, Haraldsdottir J, et al. (2002) Use of dietary supplements in Denmark is associated with health and former smoking. Public Health Nutr 5:463–468

    Article  Google Scholar 

  26. Gregory J, Foster K, Tyler H, et al. (1990) The dietary and nutritional survey of British adults. HMSO, London

  27. Marques-Vidal P, Arveiler D, Evans A, et al. (2000) Characteristics of male vitamin supplement users aged 50–59 years in France and Northern Ireland: the PRIME Study.Prospective Epidemiological Study of Myocardial Infarction. Int J Vitam Nutr Res 70:102–109

    Article  CAS  Google Scholar 

  28. Clavel-Chapelon F, van Liere MJ, Giubout C, et al. (1997) E3N, a French cohort study on cancer risk factors.E3N Group. Etude Epidémiologique auprès de femmes de l’Education Nationale. Eur J Cancer Prev 6:473–478

    CAS  Google Scholar 

  29. van Liere MJ, Lucas F, Clavel F, et al. (1997) Relative validity and reproducibility of a French dietary history questionnaire. Int J Epidemiol 26:S128–S136

    Article  Google Scholar 

  30. Lucas F, Niravong M, Villeminot S, et al. (1995) Estimation of food portion size using photographs: validity, strengths, weaknesses and recommendations. J Human Nutr Dietetics 8:65–74

    Google Scholar 

  31. Favier JC, Ireland-Ripert J, Toque C, et al. (1995) Répertoire général des aliments. Table de composition (Food composition table) CIQUAL-REGAL. TecandDoc/Lavoisier/INRA, Paris

  32. Riboli E (1992) Nutrition and cancer: background and rationale of the European Prospective Investigation into Cancer and Nutrition (EPIC). Ann Oncol 3:783–791

    CAS  Google Scholar 

  33. Carriquiry AL (1999) Assessing the prevalence of nutrient inadequacy. Public Health Nutr 2:23–33

    Article  CAS  Google Scholar 

  34. de Lauzon B, Volatier JL, Martin A (2004) A Monte-Carlo simulation to validate the EAR cut-point method for assessing the prevalence of nutrient inadequacy at the population level. Public Health Nutr 7:893–900

    Article  CAS  Google Scholar 

  35. Institute of Medicine (2004) Dietary reference intakes: guiding principles for nutrition labeling and fortification. Nutr Rev 62:73–79

    Article  Google Scholar 

  36. Martin A (2001) Nutritional Recommendations for the French Population. Sci Aliments 21:309–458

    Google Scholar 

  37. Guilbert P, Perrin-Escalon H (2004) Baromètre Santé Nutrition 2002. INPES, Saint-Denis

  38. Blendon RJ, DesRoches CM, Benson JM, et al. (2001) Americans’views on the use and regulation of dietary supplements. Arch Intern Med 161:805–810

    Article  CAS  Google Scholar 

  39. Chang CH, Chiang TL (2002) Vitamin/ calcium supplement use in Taiwan: findings from the 1994 National Health Interview Survey. Kaohsiung J Med Sci 18:171–181

    Google Scholar 

  40. Kato I, Nomura AM, Stemmermann GN, et al. (1992) Vitamin supplement use and its correlates among elderly Japanese men residing on Oahu, HI. Public Health Rep 107:712–717

    CAS  Google Scholar 

  41. Ishihara J, Sobue T, Yamamoto S, et al. (2003) Demographics, lifestyles, health characteristics, and dietary intake among dietary supplement users in Japan. Int J Epidemiol 32:546–553

    Article  Google Scholar 

  42. Cauley JA, Robbins J, Chen Z, et al. (2003) Effects of estrogen plus progestin on risk of fracture and bone mineral density: the Women’s Health Initiative randomized trial. Jama 290:1729–1738

    Article  CAS  Google Scholar 

  43. Beitz R, Mensink GB, Hintzpeter B, et al. (2004) Do users of dietary supplements differ from nonusers in their food consumption? Eur J Epidemiol 19:335–341

    Article  Google Scholar 

  44. Balluz LS, Kieszak SM, Philen RM, et al. (2000) Vitamin and mineral supplement use in the United States. Results from the third National Health and Nutrition Examination Survey. Arch Fam Med 9:258–262

    Article  CAS  Google Scholar 

  45. Beitz R, Mensink GB, Fischer B, et al. (2002) Vitamins–dietary intake and intake from dietary supplements in Germany. Eur J Clin Nutr 56:539–545

    Article  CAS  Google Scholar 

  46. Touvier M, Boutron-Ruault MC, Volatier JL, et al. (2005) Efficacy and safety of regular vitamin and mineral supplement use in France.Results from the ECCA study. Int J Vitam Nutr Res 75:201–209

    Article  CAS  Google Scholar 

  47. Flynn A, Moreiras O, Stehle P, et al. (2003) Vitamins and minerals: a model for safe addition to foods. Eur J Nutr 42:118–130

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. AFSSA—French Food Safety Agency DERNS/OCA, Maisons-Alfort, France

    M. Touvier & J.-L. Volatier

  2. INSERM, Equipe E3N, EMT, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805, Villejuif Cedex, France

    E. Kesse, F. Clavel-Chapelon & M.-Ch. Boutron-Ruault

Authors
  1. M. Touvier
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  2. E. Kesse
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  3. J.-L. Volatier
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  4. F. Clavel-Chapelon
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  5. M.-Ch. Boutron-Ruault
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Correspondence to M.-Ch. Boutron-Ruault.

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Touvier, M., Kesse, E., Volatier, JL. et al. Dietary and cancer–related behaviors of vitamin/mineral dietary supplement users in a large cohort of French women. Eur J Nutr 45, 205–214 (2006). https://doi.org/10.1007/s00394-006-0587-x

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  • DOI: https://doi.org/10.1007/s00394-006-0587-x

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