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Alpha-1-antitrypsin types in five Chinese national minorities

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Summary

The frequencies of alpha-1-antitrypsin alleles were determined for five Chinese national minorities: Uigur, Korean, Mongolian, Chuang, and Li. PI*S and PI*Z alleles are not found in the five populations studied. PI*ETOK allele is present in Korean, Mongolian, and Chuang populations, and Etokyo is a very common alpha-1-antitrypsin variant in Chinese. Other alleles which occur in more than one of the minorities are PI*X (Mongolian and Chuang) and PI*M4 (Korean and Uigur). The high frequency of PI*M4 in the Uigur population suggests a probably Occidental origin of this nationality.

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Authors and Affiliations

  1. Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing, China

    Ying Qi-long, Zhang Mei-lin & Liang Chih-chuan

  2. Department of Biochemistry, Hainan University School of Medicine, Guangdong, China

    Chen Li-chang & Chen Luo-fu

  3. Department of medicine, 303 PLA Hospital, Guangxi, China

    Huang You-wen, Wang Rong-xin & Zhang Ni-jia

  4. Department of Human Genetics, PLA General Hospital of Urumgi, Xinjiang, China

    Li Hou-jun

  5. Clinical Laboratory, 253 PLA Hospital, Inner Mongolia, China

    Liu Shi-shan & Gao Er-xi

Authors
  1. Ying Qi-long
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  2. Zhang Mei-lin
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  3. Liang Chih-chuan
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  4. Chen Li-chang
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  5. Chen Luo-fu
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  6. Huang You-wen
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  7. Wang Rong-xin
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  8. Zhang Ni-jia
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  9. Li Hou-jun
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  10. Liu Shi-shan
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  11. Gao Er-xi
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Qi-long, Y., Mei-lin, Z., Chih-chuan, L. et al. Alpha-1-antitrypsin types in five Chinese national minorities. Hum Genet 71, 225–226 (1985). https://doi.org/10.1007/BF00284579

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  • DOI: https://doi.org/10.1007/BF00284579

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