Abstract
The pulmonary effects of hyperventilation following infusion of sodium salicylate into the cisterna magna was studied in 16 spontaneously breathing adult sheep. We found a fall in PaO2, a decrease in the static compliance of the respiratory system, abnormal chest roentgenographic films, and grossly abnormal lungs following 3.5 to 13 h of hyperventilation. A control group of 15 sheep (10 sheep similarly injected with sodium salicylate, but then sedated and paralyzed and ventilated at normal tidal volume and respiratory rate on a mechanical ventilator, and 5 sheep infused with saline alone and breathing spontaneously) showed no pulmonary or arterial blood gas abnormalities. We conclude that prolonged hyperventilation under the conditions of this experiment precipitated events that resulted in acute lung injury.
Article PDF
Similar content being viewed by others
References
Froman C (1968) Alterations of respiratory functions in patients with severe head injuries. Br J Anaesth 40:354
Kumar B, Ruff ST (1984) Adult respiratory distress syndrome in diabetic ketoacidosis. Intensive Care Med 10:269
West JB, Hackett P, Maret K, Milledge J, Peters CJ, Pizzo CJ, Winslow R (1982) Hypoxia at extreme altitude. Bull Eur Physiopathol Respir 18(S4):21
Askanazi J, Silverberg P, Hyman A, Rosenbaum S, Foster R, Kinney J (1979) Patterns of ventilation in postoperative and acutely ill patients. Crit Care Med 7:41
Goodman L, Gillman A (1972) The pharmacological basis of therapeutics. McMillan, New York, p 336
Forrest JB (1972) The effect of hyperventilation on pulmonary surface activity. Br J Anaesth 44:313
Greenfield LJ, Ebert PA, Benson DW (1964) Effect of positive pressure ventilation on surface tension properties of lung extracts. Anesthesiology 25:312
Wyszogrodski I, Kyei-Aboagye K, Taeusch HW, Avery ME (1975) Surfactant inactivation by hyperventilation: conservation by end expiratory pressure. J Appl Physiol 38:461
Webb HH, Tierney DF (1974) Experimental pulmonary edema due to intermittent positive pressure ventilation with high inflation pressures. Protection by positive end expiratory pressure. Am Rev Respir Dis 110:556
Kolobow T, Moretti MP, Fumagalli R, Mascheroni D, Prato P, Chen V, Joris M (1987) Severe impairement in lung function induced by high peak airway pressure mechanical ventilation. An experimental study. Am Rev Respir Dis 135:312
Dreyfuss D, Basset G, Soler P, Saumon G (1985) Intermittent positive pressure hyperventilation with high inflation pressures produces pulmonary microvascular injury in rats. Am Rev Respir Dis 132:880
Andersen R, Refstad S (1978) Adult respiratory distress syndrome precipitated by massive salicylate poisoning. Intensive Care Med 4:211
Cameron IR, Semple SJ (1968) The central respiratory stimulant action of salicylates. Clin Sci 35:391
Nunn JF (1979) Applied respiratory physiology, 2nd edn. Butterworths, London Boston, p 307
Trinder P (1954) Rapid determination of salycilate in biological fluid. Biochem J 57:301
Clements JA (1962) Surface phenomena in relation to pulmonary function. Physiologist 5:11
Armitage P (1971) Statistical methods in medical research. Blackwell, New York, p 203
Snedecor GW, Cochran WG (1967) Statistical Methods, 6 edn. Iowa State University Press, Ames, p 277
Bowers R, Brigham K, Owen P (1977) Salicylate pulmonary edema: the mechanism in sheep and review of the clinical literature. Am Rev Respir Dis 115:261
Nunn JF (1979) Applied respiratory physiology, 2nd edn. Butterworths, London Boston, p 88
Frostell C, Blomqvist H, Hedenstierna G, Halbig I, Pieper R (1987) Thoracic and abdominal lymph drainage in relation to mechanical ventilation and PEEP. Acta Anesthesiol Scand 31:405
Worthen M, Argano B, Siwadlowski W, Bruce DW, MacCanon DM, Luisada AA (1969) Mechanism of intracisternal veratrine pulmonary edema. Dis Chest 55:45
Wauchob TD, Brooks RJ, Harrison KM (1984) Neurogenic pulmonary edema. Anaesthesia 39:529
Kolobow T, Spragg R, Pierce J (1981) Massive pulmonary infarction during total cardiopulmonary bypass in unanesthesized spontaneously breathing lambs. Int J Artif Organs 4:76
Albeida S, Hansen-Flaschen JH, Lanken PN, Fishman AP (1986) Effects of increased ventilation on lung lymph flow in unanesthetized sheep. J Appl Physiol 60:2063
Dreyfuss D, Basset G, Soler P, Saumon G (1986) Permeability pulmonary edema due to ventilation with high peak pressure is related to changes in volume, not in pressure. Am Rev Respir Dis 133:A266
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Mascheroni, D., Kolobow, T., Fumagalli, R. et al. Acute respiratory failure following pharmacologically induced hyperventilation: an experimental animal study. Intensive Care Med 15, 8–14 (1988). https://doi.org/10.1007/BF00255628
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00255628