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Neurodegenerative Diseases pp 317–331Cite as

Premature Aging Syndrome

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 724))

Abstract

Hutchinson-Gilford progeria syndrome and Werner syndrome are two of the best characterized human progeroid diseases with clinical features mimicking physiological aging at an early age. Both disorders have been the focus of intense research in recent years since they might provide insights into the pathology of normal human aging. The chapter contains a detailed description of the clinical features of both disorders and then it focuses on the genetics, the resulting biochemical alterations at the protein level and the most recent findings and hypotheses concerning the molecular basis of the premature aging phenotypes. A description of available diagnostic and therapeutic approaches is included.

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Authors and Affiliations

  1. Department of Human and Environmental Sciences, Section of Medical Genetics, University of Pisa, Italy

    Fabio Coppedè

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  1. Fabio Coppedè
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Editors and Affiliations

  1. School of Science and Technology, Nottingham Trent University, Nottingham, UK

    Shamim I. Ahmad BSc, MSc, PhD

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Coppedè, F. (2012). Premature Aging Syndrome. In: Ahmad, S.I. (eds) Neurodegenerative Diseases. Advances in Experimental Medicine and Biology, vol 724. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-0653-2_24

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