Review – Mediators of Asthma SeriesReactive Oxygen Species as Mediators in Asthma
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2022, Free Radical Biology and MedicineCitation Excerpt :A further understanding of the mechanisms involved in ROS generation and clearance in ASM, their potential dysregulation and the consequences of such dysregulation across ASM derived from asthma and COPD patients compared to healthy individuals may help to identify novel more specific therapeutic targets within the ASM. Furthermore, ROS have been implicated in compromising the efficacy of currently available treatments in in vitro ASM based studies [117,273,277,279]. Further characterisation of the mechanisms behind the role of oxidative stress in; protecting ASM from heat-induced death during bronchial thermoplasty, the down regulation of β-adrenergic signalling in ASM, and in corticosteroid insensitivity in ASM may help our understanding of why some patients do not respond fully to therapy and may enable alternative therapeutic approaches to be taken.
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Author for correspondence: Paul A. J. Henricks, Department of Pharmacology and Pathophysiology, P.O. Box 80.082, 3508 TB Utrecht, The Netherlands. Tel.: 31-30-2537358 Fax: 31-30-2537420 E-mail: [email protected]