Review ArticleChemokine Receptors in Airway Disease: Which Receptors to Target?
References (83)
- et al.
New drugs for asthma
Drug Discovery Today
(1998) - et al.
The economic burden of COPD
Chest
(2000) - et al.
Eotaxin modulates myelopoiesis and mast cell development from embryonic hematopoietic progenitors
Blood
(1998) - et al.
Extension of recombinant human RANTES by the retention of the initiating methionine produces a potent antagonist
J Biol Chem
(1996) - et al.
Chemokines in allergy
Curr Op Immunol
(1999) - et al.
Recombinant human eotaxin induces oxygen radical production, Ca2+-mobilization, actin reorganization, and CD11b upregulation in human eosinophils via a pertussis toxin-sensitive heterotrimeric guanine nucleotide-binding protein
Blood
(1996) - et al.
Tryptase-chymase double-positive human mast cells express the eotaxin receptor CCR3 and are attracted by CCR3-binding chemokines
Am J Pathol
(1999) - et al.
Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4
J Biol Chem
(1998) - et al.
The T cell directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4
J Biol Chem
(1997) - et al.
Molecular cloning and functional expression of a novel CC chemokine receptor cDNA from a human basophilic cell line
J Biol Chem
(1995)
Macrophage-derived chemokine induces human eosinophil chemotaxis in a CC chemokine receptor 3- and CC chemokine receptor 4-independent manner
J Allergy Clin Immunol
Macrophage-derived chemokine is localised to thymic medullary epithelial cells and is a chemoattractant for CD3(+), CD4(+), CD8(low) thymocytes
Blood
Identification of CCR8, the receptor for human cytokine I–309
J Biol Chem
The CC chemokine I-309 inhibits CCR8-dependent infection by diverse HIV-1 strains
J Biol Chem
Organisation and differential expression of the human monocyte chemoattractant protein 1 receptor gene: Evidence for the role of the carboxy-terminal tailin receptor trafficking
J Biol Chem
Monocyte chemotactic protein-3 (MCP-3) interacts with multiple leukocyte receptors: C-C CKR1, a receptor for macrophage inflammatory protein-1 alpha/RANTES, is also a functional receptor for MCP-3
J Biol Chem
Monocyte chemotactic protein-2 (MCP-2) uses CCR1 and CCR2b as its functional receptors
J Biol Chem
Molecular cloning of the f-Met-Leu-Phe receptor from neutrophils
J Biol Chem
Genetic and physical mapping of 2q35 in the region of NRAMP and IL-8R genes: Identification of a polymorphic repeat in exon 2 of NRAMP
Genomics
The CXC chemokines growth-regulated oncogene(GRO) alpha, GRObeta and GROgamma, neutrophil-activating peptide-2 and epithelial cell-derived neutrophil-activating peptide-78 are potent agonists for the type B, but not type A human interleukin-8 receptor
J Biol Chem
Mast cell migratory response to interleukin-8 is mediated through interaction with the chemokine receptor CXCR2/interleukin-8Rb
Blood
The biologic role of interleukin-8: Functional analysis and expression of CXCR1 and CXCR2 on human eosinophils
Blood
Interleukin-8 (IL-8), melanoma growth-stimulatory activity, and neutrophil-activating peptide selectively mediate priming of the neutrophil NADPH oxidase through the type A or type B IL-8 receptor
J Biol Chem
Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration
J Biol Chem
Identification of two rat genes orthologous to the human interleukin-8 receptors
J Biol Chem
Risk factors for accelerated decline among patients with chronic obstructive pulmonary disease
Am J Respir Crit Care Med
Pathology of asthma and COPD: a synopsis
Eur Respir Rev
International union of pharmacology. XXII nomenclature for chemokine receptors
Pharmacalogical Reviews
Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation
J Exp Med
High expression of the chemokine receptor CCR3 in human blood basophils: Role in activation by eotaxin, MCP-4 and other chemokines
J Clin Invest
Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells
Science
Chemokines active on eosinophils: potential role in allergic inflammation
J Exp Med
A novel human CC chemokine, eotaxin-3, which is expressed in IL-4 stimulated vascular endothelial cells, exhibits potent activity towards eosinophils
J Immunol
The co-ordinated action of CC chemokines in the lung orchestrates allergic inflammation and airway hyper-responsiveness
J Exp Med
Targeted disruption of the chemokine eotaxin partially reduces antigen-induced tissue eosinophilia
J Exp Med
Chemokine receptor usage by human eosinophils: The importance of CCR3 demonstrated using an antagonistic monoclonal antibody
J Clin Invest
Expression of eotaxin by human lung epithelial cells: Induction by cytokines and inhibition by glucocorticoids
J Clin Invest
IL-4 induces eotaxin: a possible mechanism of selective eosinophil recruitment in helminth infection and atopy
J Immunol
Th-1 and Th2-type cytokines regulate the expression and production of eotaxin and RANTES by human lung fibroblasts
Am J Respir Cell Mol Biol
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Inflammatory chemokine eotaxin-1 is correlated with age in heroin dependent patients under methadone maintenance therapy
2018, Drug and Alcohol DependenceCitation Excerpt :Correlations between the C-C motif chemokine ligand 11 (CCL11, eotaxin-1), a chemokine, and cigarette smoking (Krisiukeniene et al., 2009; Shiels et al., 2014), asthma (Nakamura et al., 1999), and age-related neurodegenerative diseases have been reported in literature (Guerreiro and Bras, 2015; Lalli et al., 2015; Villeda et al., 2011). It has been suggested that the mechanism of action is primarily though binding to the CCR3 receptors distributed across different tissues (Owen, 2001; Xia and Hyman, 1999). In the central nervous system, the CCL11 may cross the blood-brain barrier through the transporter protein (Erickson et al., 2014), then bind to the CCR3 on the macrophage to exert the release of reactive oxygen species (Parajuli et al., 2015), which mediates the cytotoxic effect in the brain neurons.
IPS cell derived neuronal cells for drug discovery
2014, Trends in Pharmacological SciencesCitation Excerpt :One of the cardinal barriers during clinical development of pharmaceutical drug candidates is the divergence of drug efficacies in heterologous disease-modeling cells as compared with human patients. This translational dilemma is further aggravated by the limited predictivity of many animal disease models [55]. In this context, human iPS cell derived model cells may be better suited to extrapolate from in vitro disease-relevant human biology to in vivo clinical studies.
An interactive network of elastase, secretases, and PAR-2 protein regulates CXCR1 receptor surface expression on neutrophils
2014, Journal of Biological ChemistryInnate immunity in cystic fibrosis lung disease
2012, Journal of Cystic FibrosisLPS challenge in healthy subjects: An investigation of neutrophil chemotaxis mechanisms involving CXCR1 and CXCR2
2012, International ImmunopharmacologyCitation Excerpt :We have shown that CXCR1 and CXCR2 dual antagonism has a greater effect on chemotaxis than blockade of CXCR2 alone, but this does not rule out the possibility that CXCR2 antagonism alone could provide therapeutic anti-inflammatory effects while preserving host defence mechanisms. However, it should also be considered that CXCR1 plays a critical role in neutrophil activation as well as chemotaxis [13,11]. Dual CXCR1 and CXCR2 blockade would therefore be expected to offer greater suppression of neutrophil function in addition to neutrophil chemotaxis.