Elsevier

Cytokine

Volume 15, Issue 4, August 2001, Pages 232-236
Cytokine

Short Communications
PROGNOSTIC VALUE OF CYTOKINES IN SIRS GENERAL MEDICAL PATIENTS

https://doi.org/10.1006/cyto.2001.0932Get rights and content

Abstract

We studied 174 patients with SIRS criteria, 45 with sepsis, eight with severe sepsis and 13 with septic shock. Serum TNF-α, IL-6, IL-8 and IL-10 levels were raised in SIRS patients, even in those cases in which an infection could not be documented, and more intensely in severe sepsis and in patients who died (11%). The slope of the regression line between IL-10 and TNF-α was sharper in patients with severe sepsis and in those who died; an imbalance between pro- and anti-inflammatory cytokines may be related to poor prognosis. Increased IL-6 and IL-10, decreased muscle mass, raised BUN and low body temperature were all independently related to prognosis.

References (15)

  • G Friedman et al.

    Blood interleukin 10 levels parallel the severity of septic shock

    J Crit Care

    (1997)
  • JT van Dissel et al.

    Anti-inflammatory cytokine profile and mortality in febrile patients

    Lancet

    (1998)
  • RC Bone

    Toward an epidemiology and natural history of SIRS

    JAMA

    (1992)
  • F Arnalich et al.

    Relationship of plasma leptin to plasma cytokines and human survival in sepsis and septic shock

    J Infect Dis

    (1999)
  • T Taniguchi et al.

    Change in the ratio of interleukin-6 to interleukin-10 predicts a poor outcome in patients with systemic inflammatory response syndrome

    Crit Care Med

    (1999)
  • P Glynn et al.

    Circulating interleukin 6 and interleukin 10 in community acquired pneumonia

    Thorax

    (1999)
  • CA Gogos et al.

    Pro-versus anti-inflammatory cytokine profile in patients with severe sepsis: a marker for prognosis and future therapeutic options

    J Infect Dis

    (2000)
There are more references available in the full text version of this article.

Cited by (86)

  • Impact of cytokines levels and interleukin 6 (-634 C>G) polymorphism on clinical outcomes in patients with sepsis

    2020, Meta Gene
    Citation Excerpt :

    A single sepsis marker is incapable of promoting all these benefits, which requires the determination of molecules related to the inflammatory and immunosuppressive responses. The prognostic scores APACHE II (Acute Physiology and Chronic Health Evaluation II) and Sepsis-Related Organ Failure Assessment (SOFA) consider some clinical and laboratory findings and are used in ICUs for analyzing disease severity, thus predicting patient mortality (Rodríguez-Gaspar et al., 2001; Khwannimit et al., 2018). In the immune system, interferon (INF)-γ, tumor necrosis factor (TNF), and interleukins (IL; for example, IL2, IL4, IL6, and IL10) are crucial cytokines that act against infections and inflammatory processes (Lees, 2015; Mehta et al., 2018; Park et al., 2011; Atanasovska-Stojanovska et al., 2011; Brown et al., 2016).

  • Thrombocytopenia in critically ill patients with severe sepsis/septic shock: Prognostic value and association with a distinct serum cytokine profile

    2016, Journal of Critical Care
    Citation Excerpt :

    On the contrary, in our study, we did not observe any significant correlation between ANC and serum cytokine levels meaning that ANC is not a marker of the severity of the inflammatory process. Previous studies examined peripheral blood cytokine levels in patients with sepsis, in an effort to identify biomarkers helping in prognostic stratification and in clinical management of critically ill patients [23-26]. Recent studies focused on the significance of serum suPAR levels in predicting hospital mortality in patients with sepsis [27-30].

  • Treatment with a neutralising anti-rat interleukin-17 antibody after multiple-trauma reduces lung inflammation

    2015, Injury
    Citation Excerpt :

    Recently, numerous studies [1,2] focus on trauma have shown that multiple trauma (for example: burn, high energy trauma, low energy trauma in elders, and so on) is associated with the development of systemic inflammatory response syndrome and strongly correlated with Multiple Organ Dysfunction Syndrome (MODS).

View all citing articles on Scopus
f1

Correspondence to: Francisco Santolaria, Servicio de Medicina Interna, Hospital Universitario de Canarias, Universidad de La Laguna, Tenerife, Spain. E-mail:[email protected]

View full text