Regular articleEFFECTS OF A CORTICOSTEROID, BUDESONIDE, ON PRODUCTION OF BIOACTIVE IL-12 BY HUMAN MONOCYTES
References (0)
Cited by (19)
Selective abrogation of Th1 response by STA-5326, a potent IL-12/IL-23 inhibitor
2007, BloodCitation Excerpt :The production of the IL-12 family is tightly controlled by a variety of modulators, and optimal induction of IL-12 requires a combination of TLR ligand stimulation plus IFN-γ. Although there are many small molecules that inhibit IL-12 production, including steroids,45,46 1,25-dihydroxyvitamin D3,47,48 acetyl salicylic acid (ASA),49 retinoids,50 thalidomide,51 and other agents which increase intracellular cAMP such as prostaglandin E2,52 β2 agonists,53 or phosphodiesterase inhibitors,54-56 most of these small-molecule IL-12 inhibitors fail to display their inhibitory activity when IL-12 production is strongly enhanced by IFN-γ. For example, pentoxifylline and thalidomide show no inhibitory activity against IFN-γ/SAC–induced IL-12 despite their significant inhibition of IL-12 induced by SAC alone.51,56
Maternal stress and T-cell differentiation of the developing immune system: Possible implications for the development of asthma and atopy
2002, Journal of Allergy and Clinical ImmunologyA mechanism of interleukin-12 unresponsiveness associated with thermal injury
2001, Journal of Surgical ResearchRegulation of interleukin-12 production in antigen-presenting cells
2001, Advances in Immunology
- f1
Correpsondence to: Margareta Linden, Department of Cell and Molecular Biology, Astra Draco AB, Box 34, S-221 00 Lund, Sweden