Short Analytical ReviewFibrosis of the Lung and Other Tissues: New Concepts in Pathogenesis and Treatment
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2021, Sports Orthopaedics and TraumatologyEfficacy and safety of nintedanib for pulmonary fibrosis in severe pneumonia induced by COVID-19: An interventional study
2021, International Journal of Infectious DiseasesCitation Excerpt :In the present study, we investigated the efficacy and safety of nintedanib, a new antifibrotic agent for IPF, in severe COVID-19 patients. Pulmonary fibrosis is a life-threatening pathological consequence of acute and chronic interstitial lung diseases that is characterized by unsuccessful reconstruction of the injured alveolar epithelium, persistence of fibroblasts and excessive deposition of collagen (Sime and O’Reilly, 2001). Recently, a number of studies reported that pulmonary fibrosis was also occurring as a sequela of acute lung injury induced by COVID-19 (Pan et al., 2020; Schwensen et al., 2020; Tian et al., 2020; Zhou et al., 2020).
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