Abstract
Aim: Cystic fibrosis (CF) is a chronic disease that may cause a decrease in performance during daily living activities (ADL) of patients. The purpose of this study was to compare energy expenditure and muscle oxygenation(SMO2) at Glittre ADL test in CF with and without airway obstruction.
Methods: Twenty-one CF patients (11.9±3.5 years, FEV1=87.1± 24.8 %) participated in this study. Nine patients (5F, 4M) were with airway obstruction and 12 (7F, 5M) were without obstruction based on pulmonary function testing. Glittre ADL test was performed, and subjects wore a metabolic Holter during the test to measure energy expenditure (EE). Heart rate, blood pressure, oxygen saturation, dyspnea, and fatigue perception were measured. SMO2 was recorded using a portable near-infrared spectroscopy device before and after Glittre ADL test.
Results: The EE was found as 16.1±4.3 kcal without obstruction and 22.2±6.0 kcal with obstruction in CF patients (p=0.022). The change in SMO2 were significantly lower in patients without obstruction compared to those with obstruction (ΔSMO2=-5.3±4.3% vs. -11.0±5.1%, p=0.026). The mean Gilttre ADL test duration was recorded as 2.6±0.4 min in the obstructed group and 2.2±0.8 min in the without obstruction group (p=0.081).
Conclusion: Energy expenditure and muscle oxygenation have influenced by airway obstruction. Obstruction severity affects the muscle oxygen level during the activity. Increasing oxygen demand due to bronchial obstruction may increase energy expenditure during ADL activities.
Footnotes
Cite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 284.
This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2020