Subjects | 4196 | 10 463 | 1524 | 1533 |
Exacerbations | | | | |
Person-years at risk | 9330 | 22 054 | | |
Events | 4994 | 15 944 | | |
Rate per person per year | 0.53 | 0.72 | 1.13 | 0.85 |
Crude rate ratio | 1 | 1.35 (1.28–1.43) | | |
Propensity matched rate ratio | 1 | 1.30 (1.19–1.42)+ | 1 | 0.75 (0.69–0.81) |
Mortality | | | | |
Person-years at risk | 9330 | 22 054 | | |
Events | 543 | 1245 | | |
Probability at 3 years¶ % | 16.13 | 16.04 | 15.16 | 12.59 |
Crude hazard ratio | 1 | 0.98 (0.88–1.08) | | |
Propensity matched hazard ratio | 1 | 1.11 (0.95–1.26)§ | 1 | 0.83 (0.68–1.00) |
Pneumonia | | | | |
Events | 350 | 998 | | |
Percentage of total patients | 8.34 | 9.54 | 12.31 | 19.60 |
Crude risk ratio | 1 | 1.14 (1.01–1.28) | | |
Propensity matched risk ratio | 1 | 1.14 (0.96–1.34)ƒ | 1 | 1.59 (1.35–1.88) |
Time to treatment discontinuation | | | | |
Person-years at risk | ## | 20 402 | | |
Events | | 2255 | | |
Probability at 3 years¶ % | | 28.20 | 43.50 | 33.70 |
Crude hazard ratio | | | | |
Propensity matched hazard ratio | | | 1 | 0.69 (0.62–0.78) |