Table 4– Inappropriate tuberculosis (TB) treatment regimens in Africa#
First author [ref.]CountrySettingPeriod of data collectionSample size nInappropriate TB treatment regimensData quality
SCTR
Diop [17]Kenya, SenegalNational TB programmes199611183Authors: no nationally recommended treatment regimen for 6.2% of the cases in Kenya, and 1.0% in Senegal**
Van Zyl [30]South AfricaCommunity health clinic, study in children1996–200399Authors: 4% (national guidelines)
Assessed: ≥77% (WHO)
**
Salaniponi [31]MalawiNon-private for non-profit hospitals1999–20001523Assessed: 0% (all patients (with recurrent TB) were treated with a re-treatment regimen [2HRZES/1HRZE/5HRE])*****
Harries [32]MalawiPublic hospitals20011211Assessed: new smear-positive pulmonary TB: 0% inappropriate regimen 7% wrong number of tablets*****
Elmahalli [33]EgyptPublic hospital2003249Authors: type and number of prescribed drugs not conforming to DOTS recommendations: 14% in initial phase and 5% in continuation phase***
Lalya [34]BeninHospital, study in children2003–200732Assessed:
≥10% (thioacetazone regimens)
Duration too long for most children (8 months)
**
  • SC: study characteristics; TR: treatment regimens; WHO: World Health Organization; H: isoniazid; R: rifampicin; E: ethambutol; Z: pyrazinamide; S: streptomycin. *: low quality; **: moderate quality; ***: high quality. #: general population including children; : this study is also reported in table 3 (results from Nepal).