Table 1– Subject characteristics: overall and by cluster (phenotypic pattern)
Cluster
1234567All
Normal malesNormal femalesObese femalesAtopic youngerAtopic with high eNOAtopic males with poor FEV1Atopic with BHR
Total n4674772503301301032121969
Clustering variables
 Females0.298.586.436.436.217.558.550.6
 Age yrs61±1554±1758±1540±1348±1970±1253±1854±17
 Atopic status % positive35.136.728.470.086.263.170.349.1
 BHR % positive0.00.00.40.016.212.6100.012.5
 FEV1 % pred101.499.794.299.897.266.788.696.3
 FEV1/FVC76.479.280.381.176.856.174.477.1
 eNO ppb19.515.816.916.056.122.123.420.7
 Eosinophil count ×109 L-10.170.150.220.270.310.290.240.21
 Neutrophil count ×109 L-13.062.933.824.433.164.333.573.48
 BMI kg·m−227.224.033.726.425.726.726.826.9
Nonclustering variables
 DDA6.911.716.420.930.033.039.618.0
 Recent wheeze15.012.825.626.733.854.438.223.6
 Cough/phlegm22.715.720.025.822.338.827.422.5
 DDB13.318.428.017.324.632.025.920.2
 Never smoked45.860.250.849.166.920.446.750.6
 Ex-smoker <5 pack-yrs11.316.19.610.68.57.812.711.9
 Ex-smoker >5 pack-yrs36.017.226.016.420.058.324.525.7
 Current smoker <5 pack-yrs0.61.51.27.32.30.02.82.3
 Current smoker >5 pack-yrs6.25.012.416.72.313.613.29.3
  • Data are presented as % or mean±sd, unless otherwise stated. eNO: exhaled nitric oxide; FEV1: forced expiratory volume in 1 s; BHR: bronchial hyperreactivity; % pred: % predicted; FVC: forced vital capacity; BMI: body mass index; DDA: doctor-diagnosed asthma; DDB: doctor-diagnosed bronchitis.