Cluster | ||||||||
1 | 2 | 3 | 4 | 5 | 6 | 7 | All | |
Normal males | Normal females | Obese females | Atopic younger | Atopic with high eNO | Atopic males with poor FEV1 | Atopic with BHR | ||
Total n | 467 | 477 | 250 | 330 | 130 | 103 | 212 | 1969 |
Clustering variables | ||||||||
Females | 0.2 | 98.5 | 86.4 | 36.4 | 36.2 | 17.5 | 58.5 | 50.6 |
Age yrs | 61±15 | 54±17 | 58±15 | 40±13 | 48±19 | 70±12 | 53±18 | 54±17 |
Atopic status % positive | 35.1 | 36.7 | 28.4 | 70.0 | 86.2 | 63.1 | 70.3 | 49.1 |
BHR % positive | 0.0 | 0.0 | 0.4 | 0.0 | 16.2 | 12.6 | 100.0 | 12.5 |
FEV1 % pred | 101.4 | 99.7 | 94.2 | 99.8 | 97.2 | 66.7 | 88.6 | 96.3 |
FEV1/FVC | 76.4 | 79.2 | 80.3 | 81.1 | 76.8 | 56.1 | 74.4 | 77.1 |
eNO ppb | 19.5 | 15.8 | 16.9 | 16.0 | 56.1 | 22.1 | 23.4 | 20.7 |
Eosinophil count ×109 L-1 | 0.17 | 0.15 | 0.22 | 0.27 | 0.31 | 0.29 | 0.24 | 0.21 |
Neutrophil count ×109 L-1 | 3.06 | 2.93 | 3.82 | 4.43 | 3.16 | 4.33 | 3.57 | 3.48 |
BMI kg·m−2 | 27.2 | 24.0 | 33.7 | 26.4 | 25.7 | 26.7 | 26.8 | 26.9 |
Nonclustering variables | ||||||||
DDA | 6.9 | 11.7 | 16.4 | 20.9 | 30.0 | 33.0 | 39.6 | 18.0 |
Recent wheeze | 15.0 | 12.8 | 25.6 | 26.7 | 33.8 | 54.4 | 38.2 | 23.6 |
Cough/phlegm | 22.7 | 15.7 | 20.0 | 25.8 | 22.3 | 38.8 | 27.4 | 22.5 |
DDB | 13.3 | 18.4 | 28.0 | 17.3 | 24.6 | 32.0 | 25.9 | 20.2 |
Never smoked | 45.8 | 60.2 | 50.8 | 49.1 | 66.9 | 20.4 | 46.7 | 50.6 |
Ex-smoker <5 pack-yrs | 11.3 | 16.1 | 9.6 | 10.6 | 8.5 | 7.8 | 12.7 | 11.9 |
Ex-smoker >5 pack-yrs | 36.0 | 17.2 | 26.0 | 16.4 | 20.0 | 58.3 | 24.5 | 25.7 |
Current smoker <5 pack-yrs | 0.6 | 1.5 | 1.2 | 7.3 | 2.3 | 0.0 | 2.8 | 2.3 |
Current smoker >5 pack-yrs | 6.2 | 5.0 | 12.4 | 16.7 | 2.3 | 13.6 | 13.2 | 9.3 |
Data are presented as % or mean±sd, unless otherwise stated. eNO: exhaled nitric oxide; FEV1: forced expiratory volume in 1 s; BHR: bronchial hyperreactivity; % pred: % predicted; FVC: forced vital capacity; BMI: body mass index; DDA: doctor-diagnosed asthma; DDB: doctor-diagnosed bronchitis.