Table 3– Association between genetic polymorphisms and pulmonary function

Phenotype	Gene	Polymorphism	β^#	p-value
TLC % pred	GSTT1	Deletion	0.027	0.421
	GSTM1	Deletion	0.036	0.851
	GSTM3	rs1799735	0.007	0.585
		rs1332018	0.024	0.126
	GSTP1	rs1695	-0.025	0.146
	EPHX1	rs1051740	0.032	0.947
		rs2234922	0.010	0.765
		Putative phenotype	-0.025	0.826
	NAT2	rs1041983	0.028	0.256
		rs45532639	-0.015	0.111
		Acetylator status	0.003	0.314
Single-breath D_L,CO % pred	GSTT1	Deletion	0.062	0.021
	GSTM1	Deletion	0.010	0.971
	GSTM3	rs1799735	0.052	0.221
		rs1332018	-0.039	0.383
	GSTP1	rs1695	0.012	0.948
	EPHX1	rs1051740	0.047	0.616
		rs2234922	0.032	0.525
		Putative phenotype	-0.018	0.974
	NAT2	rs1041983	-0.075	0.007
		rs45532639	0.062	0.132
		Acetylator status	0.007	0.319
D_L,CO/V_A % pred	GSTT1	Deletion	0.095	0.002
	GSTM1	Deletion	-0.013	0.650
	GSTM3	rs1799735	0.017	0.585
		rs1332018	-0.053	0.098
	GSTP1	rs1695	0.035	0.243
	EPHX1	rs1051740	0.047	0.171
		rs2234922	0.022	0.529
		Putative phenotype	-0.022	0.540
	NAT2	rs1041983	-0.086	0.006
		rs45532639	-0.057	0.076
		Acetylator status	0.013	0.647

Covariates used in the analysis: sex, age, smoking exposure in pack-years, asbestos exposure in years and forced expiratory volume in 1 s. TLC: total lung capacity; % pred: % predicted; D_L,CO: diffusing capacity of the lung for carbon monoxide; V_A: alveolar volume. ^#: standardised coefficient.