Table 2– Analysis of ciliary beat frequency, beat pattern and transmission electron microscopy (EM) of patients whose initial epithelial brush biopsies suggested an isolated inner dynein arm defect or an inner dynein arm defect associated with a radial spoke defect

Patient	Suspected defect on initial sample	Condition of initial epithelial sample	Ciliary beat frequency (95% CI) Hz			Ciliary beat pattern			EM (number of ciliary cross sections observed/number of cells studied)
			Sample 1	Sample 2	Cell culture sample	Sample 1	Sample 2	Cell culture sample	Sample 1	Sample 2	Cell culture sample
1	Inner dynein arm defect	Unhealthy	10.7 (10.4–11.1)	12.9 (12.7–13.2)	12.6 (12.3–12.7)	Stiff 100%	69% normal		96% no inner dynein arms (111/9)	Inner dynein arms present: 100% (125/9)
2	Inner dynein arm defect	Unhealthy	4.6 (4.1–5.1)	13.4 (13.0–13.8)		Stiff 100%	100% normal		92% no inner dynein arms (159/14)	Inner dynein arms present: 82% (286/16)
3	Inner dynein arm defect	Unhealthy	7.6 (7.0–8.2)	11.2 (10.9–11.6)	10.4 (9.8–10.8)	Stiff 100%	51% normal	65% normal	96% no inner dynein arms (160/13)	Inner dynein arms present: 96% (152/12)	Inner dynein arms present: 98% (97/7)
4	Radial spoke defect	Unhealthy	10.6 (10.2–11.1)	12.7 (12.4–12.9)		Stiff 100%	57% normal		96% no inner dynein arms (232/16)	Inner dynein arms present: 93% (214/14)
5	Inner dynein arm defect	Healthy	11.0 (10.7–11.3)	12.5 (12.0–13.0)	9.8 (9.4–10.2)	Stiff 100%	63% normal	71% normal	97% no inner dynein arms (240/15)	Inner dynein arms present: 97% (126/10)	Insufficient for EM
6	Inner dynein arm defect	Healthy	9.4 (9.0–9.9)	12.7 (12.5–12.9)		Stiff 100%	69% normal		96% no inner dynein arms (192/12)	Inner dynein arms present: 97% (244/14)