First author [ref.] | Country | Agent | Design | Intervention | Subjects n | Duration of follow-up (months) |
Burge [11] | UK | Colophony | Longitudinal follow-up Clinic based | Alternative job in the same factory | 28 | Mean 27–29 Range 12–45 |
Rosenberg [12] | France | Isocyanates (various types) | Longitudinal follow-up Clinic based | Alternative job with intermittent exposure (n=4) or same job with improved conditions (n=3) | 27 | Mean 17 Range 1–66 |
Chan-Yeung [13] | Canada | Red cedar | Longitudinal follow-up Clinic based | Alternative area or job with intermittent exposure | 178 | Mean 48 |
Moscato [14] | Italy | Various (90% LMW agents) | Longitudinal follow-up Clinic based | Alternative job with intermittent exposure | 25 | Mean 14 se 2 |
Paggiaro [15] | Italy | Isocyanates (TDI) | Longitudinal follow-up Clinic based | Alternative area with occasional exposure (less than once a week for less than 15 min) | 16 | Median 48 Range 18–73 |
Pisati [16] | Italy | Isocyanates (TDI) | Longitudinal follow-up Clinic based | Alternative area with intermittent exposure; 15 of 17 subjects used personal protective equipment (paper mask or cartridge respirator) | 60 | Mean 60 sd 7 |
Merget [17] | Germany | Platinum salts | Retrospective cross-sectional cohort study Clinic based | Alternative job in the production building but not directly involved in production or outside of the production building | 74 | Median 54 IQR 23–84 |
Vandenplas [18] | Belgium | Latex | Longitudinal follow-up Clinic based | Exposure to less than 20 pairs of powdered latex gloves per week in the vicinity or only low-allergen sterile latex gloves used together with latex-free examination gloves | 36 | Median 56 Range 12–92 |
Bernstein [19] | USA | Latex | Retrospective study of subjects recruited by advertisement | Switch to non-latex gloves (n=19) but indirect exposure from co-workers using powdered latex gloves in 12 subjects; area transfer in one subject | 24 | Mean 47 |
Munoz [20] | Spain | Persulfate salts | Longitudinal follow-up Clinic based | Same job but no direct contact with persulfate salts | 10 | Mean 63 sd 19 Range 39–101 |
LMW: low molecular weight; TDI: toluene diisocyanate; IQR: interquartile range.