Table 1– Description of included studies
First author [ref.]CountryAgentDesignInterventionSubjects nDuration of follow-up (months)
Burge [11]UKColophonyLongitudinal follow-up
Clinic based
Alternative job in the same factory28Mean 27–29
Range 12–45
Rosenberg [12]FranceIsocyanates (various types)Longitudinal follow-up
Clinic based
Alternative job with intermittent exposure (n=4) or same job with improved conditions (n=3)27Mean 17
Range 1–66
Chan-Yeung [13]CanadaRed cedarLongitudinal follow-up
Clinic based
Alternative area or job with intermittent exposure178Mean 48
Moscato [14]ItalyVarious (90% LMW agents)Longitudinal follow-up
Clinic based
Alternative job with intermittent exposure25Mean 14
se 2
Paggiaro [15]ItalyIsocyanates (TDI)Longitudinal follow-up
Clinic based
Alternative area with occasional exposure (less than once a week for less than 15 min)16Median 48
Range 18–73
Pisati [16]ItalyIsocyanates (TDI)Longitudinal follow-up
Clinic based
Alternative area with intermittent exposure; 15 of 17 subjects used personal protective equipment (paper mask or cartridge respirator)60Mean 60
sd 7
Merget [17]GermanyPlatinum saltsRetrospective cross-sectional cohort study
Clinic based
Alternative job in the production building but not directly involved in production or outside of the production building74Median 54
IQR 23–84
Vandenplas [18]BelgiumLatexLongitudinal follow-up
Clinic based
Exposure to less than 20 pairs of powdered latex gloves per week in the vicinity or only low-allergen sterile latex gloves used together with latex-free examination gloves36Median 56
Range 12–92
Bernstein [19]USALatexRetrospective study of subjects recruited by advertisementSwitch to non-latex gloves (n=19) but indirect exposure from co-workers using powdered latex gloves in 12 subjects; area transfer in one subject24Mean 47
Munoz [20]SpainPersulfate saltsLongitudinal follow-up
Clinic based
Same job but no direct contact with persulfate salts10Mean 63
sd 19
Range 39–101
  • LMW: low molecular weight; TDI: toluene diisocyanate; IQR: interquartile range.