All subjects | Phenotype A | Phenotype B | Phenotype C | Phenotype D | |
Subjects n (%) | 1895 (100.0) | 685 (36.1) | 363 (19.2) | 548 (28.9) | 299 (15.8) |
Age ≥40 yrs | 0.60 | 0.50 | 0.76 | 0.55 | 0.73 |
Male sex | 0.41 | 0.49 | 0.25 | 0.46 | 0.33 |
Age at asthma onset yrs | |||||
≤4 | 0.16 | 0.20 | 0.04 | 0.16 | 0.20 |
4–16 | 0.30 | 0.40 | 0.12 | 0.38 | 0.17 |
>16 | 0.54 | 0.40 | 0.84 | 0.46 | 0.63 |
Woken by coughing# | 0.45 | 0.45 | 0.79 | 0.26 | 0.35 |
Asthma symptom score# | |||||
0 symptom | 0.24 | 0.03 | 0.02 | 0.52 | 0.50 |
1–2 symptoms | 0.40 | 0.38 | 0.30 | 0.45 | 0.48 |
≥3 symptoms | 0.36 | 0.59 | 0.67 | 0.03 | 0.02 |
Chronic cough or phlegm | 0.22 | 0.24 | 0.46 | 0.09 | 0.17 |
Asthma attack# | 0.43 | 0.75 | 0.73 | 0.06 | 0.04 |
Exacerbation# | 0.10 | 0.17 | 0.22 | 0.00 | 0.01 |
Asthma treatment¶ | |||||
No treatment | 0.44 | 0.08 | 0.20 | 0.75 | 0.79 |
Other than daily ICS | 0.39 | 0.64 | 0.49 | 0.19 | 0.18 |
Daily ICS | 0.17 | 0.28 | 0.31 | 0.06 | 0.03 |
Eczema | 0.57 | 0.63 | 0.44 | 0.59 | 0.58 |
Rhinitis | 0.65 | 0.78 | 0.54 | 0.75 | 0.31 |
Atopy | 0.64 | 0.96 | 0.05 | 0.98 | 0.00 |
IgE ≥100 IU·mL−1 | 0.46 | 0.74 | 0.15 | 0.50 | 0.11 |
FEV1 <80% pred | 0.13 | 0.19 | 0.18 | 0.05 | 0.08 |
AHR+ | 0.48 | 0.76 | 0.44 | 0.36 | 0.20 |
Data are presented as the probability of individuals presenting the characteristics, unless otherwise stated. ICS: inhaled corticocosteroid; Ig: immunoglobulin; FEV1: forced expiratory volume in 1 s; % pred: % predicted; AHR: airway hyperresponsiveness. #: in the previous 12 months; ¶: in the previous 3 months; +: provocative dose causing a 20% fall in FEV1 ≤1 mg methacholine.